The Role of Renin: Angiotensin: Aldosterone System in the Pathogenesis and Pathophysiology of COVID-19

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2021-06-26 DOI:10.5772/intechopen.96478

Ozlem G. Sahin

引用次数: 0

Abstract

The novel coronavirus also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whose origin is still having uncertainties related to the existence of an intermediate host, has created the currently ongoing pandemic of coronavirus disease 2019. (COVID-19) The binding assays of SARS-CoV-2 spike protein receptor binding domain disclosed enhanced affinity with human angiotensin II-converting enzyme receptor (hACE2) comparing to the bat ACE2 receptors. ACE2, is an essential component of the regulatory mechanism of the renin-angiotensin-aldosterone system, (RAAS) and this pathway is considered to interact with the pathophysiology of COVID-19. In this chapter, we will discuss the key role of RAAS in the pathogenesis of SARS-CoV-2.

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肾素-血管紧张素-醛固酮系统在COVID-19发病机制和病理生理中的作用

新型冠状病毒也被称为严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)，其起源仍与中间宿主的存在存在不确定性，造成了目前正在进行的2019冠状病毒病大流行。(COVID-19) SARS-CoV-2刺突蛋白受体结合域与人血管紧张素ii转换酶受体(hACE2)的结合分析显示，与蝙蝠的ACE2受体相比，其亲和力增强。ACE2是肾素-血管紧张素-醛固酮系统(RAAS)调控机制的重要组成部分，该途径被认为与COVID-19的病理生理相互作用。在本章中，我们将讨论RAAS在SARS-CoV-2发病机制中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.