Production of antibiotics by Epidermophyton floccosum. 5. Relation between the "epidermophyton factor" (EPF) and some steroid antibiotics, particularly fucidin.

Abstract

The “Epidermophyton factor” (EPF) was formed best on cultivation in medium where the reaction was maintained alkaline. The substance gave the chemical colour reactions expected of a steroid. In these reactions and in comparative chromatography EPF closely resembled fucidin, but it was found to be a less acid substance. Nor was EPF identical with 3-keto-fusidic acid, helvolic acid or cephalosporin P1.