Inclusion Complex of Thiourea Substrate with Hydroxypropyl-β-cyclodextrin

A. Allouch, I. Hassan, Adib Abou Dalle, H. El-Nakat, F. Omar
{"title":"Inclusion Complex of Thiourea Substrate with Hydroxypropyl-β-cyclodextrin","authors":"A. Allouch, I. Hassan, Adib Abou Dalle, H. El-Nakat, F. Omar","doi":"10.7598/CST2013.402","DOIUrl":null,"url":null,"abstract":"To be active, a heavy metal trap substrate must possess some degree of aqueous solubility. The use of cyclodextrins molecules, which can form inclusion complexes with the hydrophobic trap substrates, has provided the required solubility through the relatively hydrophobic cavity of native cyclodextrins and their derivatives that enhances the ability to complex hydrophobic substrates of appropriate size and shape. In this study, spectrophotometry has been used to investigate the effects of cyclodextrin on the solubility, stoichiometry and stability of the substrate-CD complex formed between N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, (a hydrophobic substrate trap) and hydroxypropyl-β-cyclodextrin (HP−β−CD). The solubility, stoichiometry and overall association constant of the complex have been determined using the Higuchi's method, the continuous variation (Job's plot) method and the Scott's method respectively.","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":"37 1","pages":"663-669"},"PeriodicalIF":0.0000,"publicationDate":"2013-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical science transactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/CST2013.402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

To be active, a heavy metal trap substrate must possess some degree of aqueous solubility. The use of cyclodextrins molecules, which can form inclusion complexes with the hydrophobic trap substrates, has provided the required solubility through the relatively hydrophobic cavity of native cyclodextrins and their derivatives that enhances the ability to complex hydrophobic substrates of appropriate size and shape. In this study, spectrophotometry has been used to investigate the effects of cyclodextrin on the solubility, stoichiometry and stability of the substrate-CD complex formed between N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, (a hydrophobic substrate trap) and hydroxypropyl-β-cyclodextrin (HP−β−CD). The solubility, stoichiometry and overall association constant of the complex have been determined using the Higuchi's method, the continuous variation (Job's plot) method and the Scott's method respectively.
硫脲底物与羟丙基-β-环糊精的包合物
为了具有活性,重金属捕集器底物必须具有一定程度的水溶性。环糊精分子可以与疏水陷阱底物形成包合物,通过天然环糊精及其衍生物的相对疏水腔提供所需的溶解度,从而增强了与适当大小和形状的疏水底物复合的能力。本研究采用分光光度法研究了环糊精对N-(2-乙基苯基)-N'-(2-甲基苯基)硫脲(疏水底物陷阱)和羟丙基-β-环糊精(HP−β−CD)形成的底物-CD配合物的溶解度、化学计量学和稳定性的影响。分别用Higuchi法、连续变化(Job’s plot)法和Scott法测定了络合物的溶解度、化学计量和总缔合常数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信