Ultrasound Promoted One-Pot Multicomponent Synthesis of Highly Functionalized Tetrahydropyridine Derivatives

IF 2.4 3区 化学 Q2 CHEMISTRY, ORGANIC
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引用次数: 0

Abstract

The N-methyl pyridinium tosylate (NMPyTs) ionic liquid is used as an efficient, homogeneous, and recyclable catalyst for the synthesis of tetrahydropyridine derivatives via one-pot multi-component condensation of aromatic aldehyde, anilines, and β-ketoesters under ultrasonic irradiations. This protocol was successfully pertinent to a wide range of structurally diverse aromatic aldehydes, substituted anilines, and β-ketoesters. The major characteristics of this technique include operational simplicity, short reaction times, mild reaction conditions, and high yield. Importantly, NMPyTs can undergo up to three recycle runs without any noticeable loss of catalytic activity.

超声波促进高官能化四氢吡啶衍生物的单锅多组分合成
N 甲基吡啶鎓对甲苯磺酸盐(NMPyTs)离子液体被用作一种高效、均相和可回收的催化剂,用于在超声波辐照下通过芳香醛、苯胺和 β 酮酯的单锅多组分缩合合成四氢吡啶衍生物。该方法成功地适用于多种结构不同的芳香醛、取代苯胺和 β-酮酯。该技术的主要特点包括操作简单、反应时间短、反应条件温和以及产率高。重要的是,NMPyTs 最多可循环使用三次,而不会明显丧失催化活性。
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来源期刊
Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds 化学-有机化学
CiteScore
3.70
自引率
20.80%
发文量
412
审稿时长
3 months
期刊介绍: The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.
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