The theory of free radicals and aging: A review article

Abstract

Introduction: Biological aging is not something that only occurs in older people, but it’s a continuous process and natural that begins at puberty and ultimately leads to death. The aim of this study is to investigate the theory of free radicals and aging and its related aspects. Methods: This study is a narrative review study. That was done by searching the databases of SID, Irandoc, Magiran, Google Scholar, Pub Med, and Science Direct with the keywords free radicals, aging, and free radicals theory in aging. Results:The production of free radicals occurs in all cells, and in spite of their inactivation by intracellular antioxidants, they exert their effects on the cells, and accumulation of these effects over time may impair cell function, and this should be noted. That cannot be stopped, and as said, antioxidants only affect the average lifespan and are ineffective in maximizing longevity. Conclusions: Daily intake of non-enzymatic oral antioxidants can affect many diseases such as cancer, atherosclerosis, stroke, neurodegenerative diseases and diabetes, but it has no effect on maximizing lifespan.