Accuracy of transient elastography in Identifying fibrosis among patients with Chronic hepatitis b: a cross-sectional Observational study

Bangladesh Journal of Veterinary Medicine Pub Date : 2023-09-03 DOI:10.3329/bjm.v34i3.68423

Rajib Saha Rony, Ahmed Hossain, Md Daharul Islam, Md Fazal Karim, Aminur Rahman, Sudipta Saha Jui

{"title":"Accuracy of transient elastography in Identifying fibrosis among patients with Chronic hepatitis b: a cross-sectional Observational study","authors":"Rajib Saha Rony, Ahmed Hossain, Md Daharul Islam, Md Fazal Karim, Aminur Rahman, Sudipta Saha Jui","doi":"10.3329/bjm.v34i3.68423","DOIUrl":null,"url":null,"abstract":"Background: Hepatitis B virus (HBV) infection is a significant global public health problem, affecting millions of people worldwide. Liver biopsy is the gold standard for assessing fibrosis but is invasive and carries post-procedural risks. Noninvasive tests to evaluate liver fibrosis are needed, and transient elastography is one such method. This cross-sectional observational study aimed to assess the accuracy of transient elastography in identifying fibrosis among patients with chronic hepatitis B. \nMethods: The study was conducted at the Department of Medicine and Hepatology, Sir Salimullah Medical College Mitford Hospital, Dhaka. The study subjects were patients diagnosed with chronic hepatitis B infection, both outpatient and inpatient cases. Data were collected from 25 patients using convenient and purposive sampling techniques. Demographic data, clinical examination, and relevant investigations were recorded in a structured case report form. Data were processed, registered, edited, computerized, and analyzed. \nResults: The study included 25 patients with a mean age of 26.8±6.5 years, predominantly male (80%). All patients were HBsAg positive, 12.0% were HBeAg positive, and 56.0% were antiHBe positive. The mean HBV DNA PCR was 1516293.4±7475976.3 IU/ml. The mean ALT level was 45.4±13.8 U/L. The mean liver stiffness measurement (LSM) was 7.5±2.3 kPa, with 64.0% of patients showing fibrosis stage F0-F1. The mean periportal +/- bridging necrosis was 2.92±1.58, intralobular degeneration and focal were 1.16±0.55, portal inflammation was 2.52±0.87, histological activity index was 6.6±2.2, and fibrosis score was 1.44±1.04. Positive correlations were observed between LSM and histological activity index (r=0.239; p=0.251) and between LSM and fibrosis score (r=0.107; p=0.612). \nConclusion: Our study demonstrates that transient elastography provides a non-invasive, easy, and cost-effective method for identifying fibrosis in chronic hepatitis B patients, serving as a potential alternative to liver biopsy. \nBangladesh J Medicine 2023; 34(3): 199-205","PeriodicalId":8721,"journal":{"name":"Bangladesh Journal of Veterinary Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Journal of Veterinary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/bjm.v34i3.68423","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Hepatitis B virus (HBV) infection is a significant global public health problem, affecting millions of people worldwide. Liver biopsy is the gold standard for assessing fibrosis but is invasive and carries post-procedural risks. Noninvasive tests to evaluate liver fibrosis are needed, and transient elastography is one such method. This cross-sectional observational study aimed to assess the accuracy of transient elastography in identifying fibrosis among patients with chronic hepatitis B. Methods: The study was conducted at the Department of Medicine and Hepatology, Sir Salimullah Medical College Mitford Hospital, Dhaka. The study subjects were patients diagnosed with chronic hepatitis B infection, both outpatient and inpatient cases. Data were collected from 25 patients using convenient and purposive sampling techniques. Demographic data, clinical examination, and relevant investigations were recorded in a structured case report form. Data were processed, registered, edited, computerized, and analyzed. Results: The study included 25 patients with a mean age of 26.8±6.5 years, predominantly male (80%). All patients were HBsAg positive, 12.0% were HBeAg positive, and 56.0% were antiHBe positive. The mean HBV DNA PCR was 1516293.4±7475976.3 IU/ml. The mean ALT level was 45.4±13.8 U/L. The mean liver stiffness measurement (LSM) was 7.5±2.3 kPa, with 64.0% of patients showing fibrosis stage F0-F1. The mean periportal +/- bridging necrosis was 2.92±1.58, intralobular degeneration and focal were 1.16±0.55, portal inflammation was 2.52±0.87, histological activity index was 6.6±2.2, and fibrosis score was 1.44±1.04. Positive correlations were observed between LSM and histological activity index (r=0.239; p=0.251) and between LSM and fibrosis score (r=0.107; p=0.612). Conclusion: Our study demonstrates that transient elastography provides a non-invasive, easy, and cost-effective method for identifying fibrosis in chronic hepatitis B patients, serving as a potential alternative to liver biopsy. Bangladesh J Medicine 2023; 34(3): 199-205

查看原文本刊更多论文

瞬变弹性成像识别慢性乙型肝炎纤维化的准确性:一项横断面观察性研究

背景:乙型肝炎病毒(HBV)感染是一个重大的全球公共卫生问题，影响着全世界数百万人。肝活检是评估纤维化的金标准，但它是侵入性的，并有术后风险。评估肝纤维化需要无创试验，瞬态弹性成像就是其中一种方法。这项横断面观察性研究旨在评估瞬时弹性成像识别慢性乙型肝炎患者纤维化的准确性。方法:该研究在达卡萨里穆拉爵士医学院米特福德医院医学和肝病学系进行。研究对象是诊断为慢性乙型肝炎感染的患者，包括门诊和住院病例。采用方便、有目的的抽样技术收集25例患者的数据。人口统计资料、临床检查和相关调查记录在结构化的病例报告表格中。数据经过处理、登记、编辑、计算机化和分析。结果:研究纳入25例患者，平均年龄26.8±6.5岁，以男性为主(80%)。所有患者HBsAg阳性，HBeAg阳性12.0%，抗hbe阳性56.0%。HBV DNA PCR平均为1516293.4±7475976.3 IU/ml。ALT平均为45.4±13.8 U/L。肝硬度测量平均值(LSM)为7.5±2.3 kPa, 64.0%的患者表现为F0-F1期纤维化。门静脉周围+/-桥性坏死平均为2.92±1.58，小叶内变性和局灶性坏死平均为1.16±0.55，门静脉炎症平均为2.52±0.87，组织学活性指数为6.6±2.2，纤维化评分为1.44±1.04。LSM与组织学活性指数呈正相关(r=0.239;p=0.251)， LSM与纤维化评分之间(r=0.107;p = 0.612)。结论:我们的研究表明，瞬时弹性成像提供了一种无创、简单、经济的方法来识别慢性乙型肝炎患者的纤维化，可作为肝活检的潜在替代方法。孟加拉国J医学2023;34 (3): 199 - 205

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bangladesh Journal of Veterinary Medicine

自引率

0.00%

发文量