Topic - Controlled Drug Release by Excipient Modification: A Review

Abstract

Excipients play an essential role in the physical and chemical characteristics of the oral dosage form. The excipient modification can alter the parameters like dissolution and disintegration. Oral dosage form passes through the varying pH of the human gastrointestinal tract and delivers the drug at a specific site. For providing pH-responsive dosage form, novel techniques are used, which include hydrogels, nanoparticles, and microspheres. The article also reviews problems related to drug excipient interactions and questions related to delivering the drug to specific targets by showing pH-responsive drug release. The addition of excipients like lignin can achieve a better pH modified version and controlled release of the active pharmaceutical excipient. The biopolymer lignin can be altered due to many functional groups in its chemical structure. The use of lignin can help to release the drug in specific targets within the gastrointestinal tract. The use of natural polymers should be increased to manufacture eco-friendly and economical dosage forms.