[Changes in the content of reduced glutathione in severe injuries and multiple trauma].

Abstract

We explored the changes in reduced glutathione in pathogenesis of severe and combined trauma. Under conditions of our experiments both in blood plasma and tissue of liver, kidneys and heart the concentration of reduced glutathione is decreased. Comparison of the changes ofglutathione that occur in animals of the first experimental group (only severe group) with the same in animals of the second and the third groups, caused by the influence of extra mechanical defect and skin burn, showed that in the last group the disorders of functional status system of antioxidant protection occur more often than in only severely injured animals. The largest significant decrease (34%) in the content of GSH on the 3rd day after injury we found in liver of seriously injured burned animals. In animals of the first and second groups the content of GSH decreased by 27 and 33.7%, respectively.