Preparation of 1-Alkyl-2,5-piperazinediones*

Abstract

General methods for the preparation of 1-alkyl-2,5-piperazinediones were found in the cyclization of N-alkylglycylglycines and the alkylation of the sodium salt of 1-acetyl-2,5-piperazinedione. 1-Methyl-2,5-piperazinedione showed significant antispasmodic activity.