Synthesis Characterization and Biological Influence of Some NewlySynthesized Mix ligand Chelates

Abstract

Objective: A series of mixed ligand chelates of d10 were synthesized expending 3TC a potent nucleoside analogue and ACV, is a guanosine analogue antiviral drug. Methods: The synthesized chelates were characterized by IR, Mass spectra, TGA analysis and Elemental analysis and were evaluated for their anti-fungal activity against a panel of two pathogenic fungal strains namely, Aspergillus niger, and Candida albicans by Broth-dilution method, antibacterial activity against E. coli, P. aeruginosa, S. aureus, S. pyogenus. Results: All the compounds showed significant inhibitory activity against the microorganism. Anti-bacterial activity was determined using Ampicillin as a standard and antifungal activity was determined using standard Greseofulvin. Conclusion: Out of all the chelates, the chelate of Cd2+ exhibited promising antimicrobial activity as a whole.