AMADORIASE ENGINEERED ENZYME FOR PROTEIN DEGLYCATION

Abstract

The progressive accumulation of Advanced Glycation End-product (AGEs) in the human body leads to several deleterious consequences, involving tissues stiffening and pathologies (aterosclerosis, nephropathy, and Alzheimer’s disease). Nowadays there are no effective therapies against AGEs build-up, although a promising strategy is redeglycating enzymes (FAOXs), which are however inactive towards entire proteins due to their buried active site.