Moderate‐ and High‐Intensity Exercise Improves Lipoprotein Profile and Cholesterol Efflux Capacity in Healthy Young Men

K. Stanton, V. Kienzle, D. Dinnes, Irina Kotchetkov, W. Jessup, L. Kritharides, D. Celermajer, K. Rye
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引用次数: 6

Abstract

Background Exercise is associated with a reduced risk of cardiovascular disease. Increased high‐density lipoprotein cholesterol (HDL‐C) levels are thought to contribute to these benefits, but much of the research in this area has been limited by lack of well‐controlled subject selection and exercise interventions. We sought to study the effect of moderate and high‐intensity exercise on HDL function, lipid/lipoprotein profile, and other cardiometabolic parameters in a homogeneous population where exercise, daily routine, sleep patterns, and living conditions were carefully controlled. Methods and Results Male Army recruits (n=115, age 22±0.3 years) completed a 12‐week moderate‐intensity exercise program. A subset of 51 subsequently completed a 15‐week high‐intensity exercise program. Fitness increased and body fat decreased after moderate‐ and high‐intensity exercise (P<0.001). Moderate‐intensity exercise increased HDL‐C and apolipoprotein A‐I levels (6.6%, 11.6% respectively), and decreased low‐density lipoprotein cholesterol and apolipoprotein B levels (7.2%, 4.9% respectively) (all P<0.01). HDL‐C and apolipoprotein A‐I levels further increased by 8.2% (P<0.001) and 6.3% (P<0.05) after high‐intensity exercise. Moderate‐intensity exercise increased ABCA‐1 (ATP‐binding cassette transporter A1) mediated cholesterol efflux by 13.5% (P<0.001), which was sustained after high‐intensity exercise. In a selected subset the ability of HDLs to inhibit ICAM‐1 (intercellular adhesion molecule‐1) expression decreased after the high (P<0.001) but not the moderate‐intensity exercise program. Conclusions When controlling for exercise patterns, diet, and sleep, moderate‐intensity exercise improved HDL function, lipid/lipoprotein profile, fitness, and body composition. A sequential moderate followed by high‐intensity exercise program showed sustained or incremental benefits in these parameters. Improved HDL function may be part of the mechanism by which exercise reduces cardiovascular disease risk.
中、高强度运动可改善健康青年男性的脂蛋白谱和胆固醇外排能力
运动与降低心血管疾病的风险有关。高密度脂蛋白胆固醇(HDL - C)水平的增加被认为有助于这些益处,但由于缺乏控制良好的受试者选择和运动干预,该领域的许多研究受到限制。我们试图研究中等和高强度运动对高密度脂蛋白功能、脂质/脂蛋白谱和其他心脏代谢参数的影响,在一个均匀的人群中,运动、日常生活、睡眠模式和生活条件都受到严格控制。方法与结果115名男性新兵(年龄22±0.3岁)完成了为期12周的中等强度锻炼计划。51人随后完成了为期15周的高强度锻炼计划。中强度和高强度运动后,体能增加,体脂减少(P<0.001)。中等强度运动增加了HDL - C和载脂蛋白A - I水平(分别为6.6%和11.6%),降低了低密度脂蛋白胆固醇和载脂蛋白B水平(分别为7.2%和4.9%)(均P<0.01)。高强度运动后HDL - C和载脂蛋白A - I水平分别升高8.2% (P<0.001)和6.3% (P<0.05)。中等强度运动使ABCA - 1 (ATP结合盒转运蛋白A1)介导的胆固醇外排增加13.5% (P<0.001),这在高强度运动后持续。在一个选定的子集中,高密度脂蛋白抑制ICAM - 1(细胞间粘附分子- 1)表达的能力在高强度运动后下降(P<0.001),但在中等强度运动后没有下降。在控制运动模式、饮食和睡眠的情况下,中等强度运动可改善HDL功能、脂质/脂蛋白谱、健康和身体成分。在这些参数中,顺序适度的高强度运动项目显示出持续或递增的益处。改善HDL功能可能是运动降低心血管疾病风险的机制之一。
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