Study on the anti-arthritic effects of Tinospora sinensis Merr.

Abstract

The Tinospora sinensis Merr. was ultrasonically extracted using 80% ethanol at a temperature of 50°C. The resulting solution was distilled to remove the solvent under reduced pressure, yielding the extract. The extract was then dissolved in distilled water, and this solution was administered to the experimental mice. The results showed that even at the maximum allowable dose, no mice experienced mortality. The anti-inflammatory effects of Tinospora sinensis Merr. extract were tested in experiments. The results demonstrated that at a dose equivalent to 1.6 g of plant material per kilogram of body weight per day, the extract exhibited acute anti-inflammatory activity in a model of carrageenan-induced foot edema in mice, comparable to a dose of 80 mg/kg body weight per day of aspirin. Additionally, at a dose equivalent to 2.8 g of plant material per kilogram of body weight per day, the extract showed chronic anti-inflammatory effects in a model of amian-induced granuloma in white mice. These findings suggest a novel direction in using plant-derived medicines, specifically the Tinospora sinensis Merr.