CIN III and cervical SCC with negative oncogenic HPV PCR: A case series

Sam Sturrock, A. Griffiths, T. Jobling
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引用次数: 0

Abstract

With the recent introduction of the renewed National Cervical Screening Program (NCSP) in Australia, utilising primary human papillomavirus (HPV) nucleic acid testing (NAT) for known oncogenic HPV types rather than cervical cytology, we reflect on three asymptomatic women with negative oncogenic HPV test results and high‐grade cervical abnormalities including cervical intraepithelial neoplasia (CIN) III and cervical squamous cell carcinoma (SCC). The two cases with CIN III had a ‘probable’ oncogenic subtype (HPV 53) identified on further testing, while the case of SCC had no HPV virus identified. These cases serve as a reminder of the need for ongoing diligence despite low‐risk screening under the new program.
CIN III和宫颈SCC伴阴性癌性HPV PCR:一个病例系列
随着澳大利亚最近更新的国家子宫颈筛查计划(NCSP)的引入,利用原发性人乳头瘤病毒(HPV)核酸检测(NAT)检测已知的致癌型HPV,而不是宫颈细胞学,我们反思了三名无症状的女性,她们的致癌型HPV检测结果阴性,宫颈高度异常,包括宫颈上皮内瘤变(CIN) III和宫颈鳞状细胞癌(SCC)。两例CIN III的病例在进一步的检测中发现了“可能的”致癌亚型(HPV 53),而SCC的病例没有发现HPV病毒。这些病例提醒我们,尽管在新计划下进行低风险筛查,但仍需要持续的尽职调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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