NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor) Drug AZT and Their Preparation & Determination A Patent Evaluation of Efavirenz

Abstract

Efavirenz, L-743725((+)-enantiomer), DMP-266, L-741211(racemate), L-743726, Stocrin, Sustiva (S)-(-)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one. Now India recommends efavirenz (EFV)based antiretroviral treatment (ART) to treat HIV, which is currently cheaper than DTG-based ART. However, as pharmaceutical licenses on DTG are now lifting in India, generic versions of DTG are likely to bring its cost close to that of EFV. Research from the USA and Europe, where DTG is recommended as the first option for treatment, suggests DTG has more tolerable side effects, can enable people to suppress HIV levels quickly and is less likely to lead to drug resistance [3].