G. D. R. Brito, A. Marreiros, Izael Francisco de Brito Araujo, Raimundo Gerônimo da Silva Júnior, I. Sene, D. C. Braz
{"title":"Severe Kala-azar and seric level of IL-6: case reports","authors":"G. D. R. Brito, A. Marreiros, Izael Francisco de Brito Araujo, Raimundo Gerônimo da Silva Júnior, I. Sene, D. C. Braz","doi":"10.12662/2317-3076jhbs.v8i1.3035.p1-4.2020","DOIUrl":null,"url":null,"abstract":"Introduction : IL-6 cytokine participates in the inflammatory process of systemic leishmaniasis and elevated levels are associated with active disease. Case reports : Three patients with different age groups and different severity scores, above 4 were reported, and IL-6 plasma concentrations and their association with disease severity were observed. Conclusion : Analysis suggests that only the score, has no sensitivity to classify, among others critically ill patients, those with imminent risk of death. IL-6 concentrations can allow this differentiation, considering that only fatal case, HBV/ Leishmania coinfection, presented expressively higher level of the cytokine concentration.","PeriodicalId":16071,"journal":{"name":"Journal of Health & Biological Sciences","volume":"74 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health & Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12662/2317-3076jhbs.v8i1.3035.p1-4.2020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Introduction : IL-6 cytokine participates in the inflammatory process of systemic leishmaniasis and elevated levels are associated with active disease. Case reports : Three patients with different age groups and different severity scores, above 4 were reported, and IL-6 plasma concentrations and their association with disease severity were observed. Conclusion : Analysis suggests that only the score, has no sensitivity to classify, among others critically ill patients, those with imminent risk of death. IL-6 concentrations can allow this differentiation, considering that only fatal case, HBV/ Leishmania coinfection, presented expressively higher level of the cytokine concentration.