Experimental substantiation of the tentatively safe level of diethyl disulfide in the air of the working area and the atmospheric air of populated areas

Semen Alexandrovich Kucherskoy, L. A. Alikbaeva, Evgenii Yrievich Karmanov, Irina Borisovna Ermakova, Diana Gaevna Oskina, Andrej Stanislavovich Radilov
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Abstract

Introduction. Diethyl disulfide belongs to the group of dialkyl disulfides, is a part of disulfide oil and a mixture of dialkyl disulfides. As a result of industrial purification of hydrocarbon raw materials from mercaptans, tens of thousands of tons of dialkyldisulfides and their mixtures are accumulated annually, the toxicity and danger of which have not been fully studied. No hygiene standards have been developed for diethyl disulfide. Materials and methods. Studies of the effects of diethyl disulfide were carried out in non-linear animals (rats and mice). The toxic properties of diethyl disulfide were studied under the conditions of single and repeated exposure to the intragastric, intraperitoneal, inhalation and cutaneous routes of entry into the body. Results. Based on the studies carried out, the toxicometric parameters of diethyl disulfide were established. Average lethal dose with intragastric administration LD50 = 1575 mg/kg, average lethal concentration CL50 = 18700 mg/m3, coefficient of possible inhalation poisoning CPIP = 1.3, limit of acute inhalation action (Limac) is set at 120 mg/m3, acute zone Zac = 156, cumulation coefficient was 3.2. Diethyl disulfide does not have a skin-resorptive toxic effect, but it has a moderately pronounced irritating effect on the mucous membrane of the eyes. Limitations of the study. The results of the diethyl disulfide exposure assessment are given for two animal species and four main routes of entry. Conclusion. The data obtained indicate that diethyl disulfide is a moderately hazardous substance with a single intragastric, inhalation and cutaneous route of entry into the body. The cumulative properties of diethyl disulfide are moderately expressed. Based on the analysis of literature data, the results of experimental studies and mathematical forecasting, a value of 4.0 mg/m3 is recommended as an approximate safe level of exposure in the air of the working area, in the atmospheric air of urban and rural settlements - 0.04 mg/m3.
二乙基二硫化物在工作区域和人口密集区域空气中暂时安全水平的实验证实
介绍。二乙基二硫化物属于二烷基二硫化物族,是二硫化物油的一部分和二烷基二硫化物的混合物。由于工业从硫醇中提纯碳氢化合物原料,每年积累数万吨二烷基二硫化物及其混合物,其毒性和危险性尚未得到充分研究。二乙基二硫化物尚未制定卫生标准。材料和方法。在非线性动物(大鼠和小鼠)中进行了二乙基二硫醚影响的研究。研究了二乙基二硫化物在经胃、腹腔、吸入和皮肤等途径进入人体的单次和多次暴露条件下的毒性。结果。在此基础上,建立了二乙基二硫醚的毒理学参数。平均灌胃致死剂量LD50 = 1575 mg/kg,平均致死浓度CL50 = 18700 mg/m3,可能吸入中毒系数CPIP = 1.3,设定急性吸入作用限值(Limac)为120 mg/m3,急性区Zac = 156,累积系数为3.2。二乙基二硫醚没有皮肤吸收毒性作用,但它对眼睛粘膜有中度明显的刺激作用。本研究的局限性。本文给出了两种动物和四条主要进入途径的二乙基二硫接触评估结果。结论。所获得的数据表明,二乙基二硫化物是一种中等危险物质,只有单一的经胃、吸入和皮肤进入人体的途径。二硫二乙酯的累积性质得到了适度的表达。根据文献资料分析、实验研究结果和数学预测,建议工作区空气中暴露量的近似安全水平为4.0 mg/m3,城乡住区大气中暴露量为0.04 mg/m3。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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