2022-RA-567-ESGO The Geneva HRD test: clinical validation on 469 samples from the PAOLA-1 trial

Abstract

2022-RA-567-ESGO Figure 1 Abstracts A238 Int J Gynecol Cancer 2022;32(Suppl 2):A1–A504 on D ecem er 4, 2022 by gest. P rocted by coright. http/ijgc.bm jcom / nt J G ynecol C acer: frst pulished as 10.11ijgc-2022-E S G O .14 on 20 O cber 222. D ow nladed fom Conclusion The proposed test is a viable alternative to the Myriad myChoice HRD test and can easily be implemented in a clinical laboratory for routine practice. The performance of the tests is similar in terms of hazard ratio but the lower failure rate of the Geneva HRD test allows a 10% increase in the number of patients receiving a conclusive laboratory result. 2022-VA-572-ESGO HUDSON POSTERIOR EXENTERATION, WITH THE USE OF ICG FLUORESCENCE TO ASSESS RECTAL ANASTOMOSIS AND URETERAL INTEGRITY Dong Bach Nguyen, Beatriz Navarro Santana, Guillaume Babin, Sara Forte, Mathilde Mairé, Frédéric Guyon. Gynécologie Oncologie, Institut Bergonié, Bordeaux, France 10.1136/ijgc-2022-ESGO.515 Introduction/Background The surgical approach to hysterectomy for ovarian cancer has remained largely unchanged since Hudson described the en-bloc resection of fixed ovarian tumors using a retrograde technique in 1968. When a colorectal resection is required for optimal debulking, anastomotic leak remains a significant concern. While the traditional techniques used to evaluate for anastomotic perfusion lack accuracy, data from a recent systematic review and meta-analysis favours the use of ICG intra-op to reduce the incidence of anastomotic leak and associated need for reintervention. Methodology With the use of surgical footage, this video aims to present the surgical steps to a Hudson procedure with colorectal resection, ending with the use of ICG fluorescence to assess the perfusion of the colorectal anastomosis and ureters. Results The surgical approach can be summarized in the following ten steps: (1) retroperitoneal dissection of the vascular pedicles and ureters, and transection of the IP ligament; (2) dissection of the paravesical and pararectal spaces; (3) lateral and pre-vesical peritonectomy; (4) ureterolysis and transection of the uterine vessels; (5) transection of the vesciouterine and uterosacral ligaments; (6) colpotomy; (7) mesorectal dissection and distal rectal transection; (8) proximal rectosigmoid transection; (9) vaginal vault closure and colorectal anastomosis; (10) assessment of colorectal anastomosis and ureteral vascularization by ICG fluorescence. Conclusion This video presented 10 reproducible steps to perform a Hudson procedure with colorectal resection for ovarian cancer. The use of ICG as an adjunct to assess the vascularization of the colorectal anastomosis appears to reduce the risk of anastomotic leak in colorectal surgery, and may be of interest in gynecologic-oncologic surgery. 2022-RA-576-ESGO EXPRESSION VIII – FIRST STUDY OF INDIVIDUAL PERCEPTION AND LEVEL OF INFORMATION OF PATIENTS WITH LOW GRADE OVARIAN CANCER AND BORDERLINE TUMOR OF THE OVARY IN 321 PATIENTS Laura Naomi Beckmann, Sara Alavi, Maren Keller, Clemens Liebrich, Karol Kubiak, Pauline Wimberger, Vera Czolk, Anette Ligl-Löhner, Hans-Martin Enzinger, Aline Burdack, Dorothea Fischer, Jürgen Terhaag, Cornelia Müller, Volker Hanf, Mateja Condic, Georg Kunz, Tilmann Lantzsch, Ute Schilling, Gülten Oskay-Özcelik, Jalid Sehouli. Department of Gynecology with Center for Oncological Surgery, European Compe-tence Center for Ovarian Cancer, Charité – Campus Virchow-Klinikum, University Medicine of Berlin, Berlin, Germany; North-Eastern German Society of Gynecological Oncology (NOGGO), Berlin, Germany; Gynäkologisches Krebszentrum, Klinikum Wolfsburg, Wolfsburg, Germany; St. Franziskus-Hospital GmbH, Münster, Germany; Department of Gynecology and Obstetrics, TU Dresden Medizinische Fakultat Carl Gustav Carus, Dresden, Germany; Diako Mannheim, Mannheim, Germany; Diakonissen-Stiftung-Krankenhaus Speyer, Speyer, Germany; Sozialstiftung Bamberg, Bamberg, Germany; Sana Klinikum Lichtenberg, Berlin, Germany; Klinikum Ernst von Bergmann gemeinnützige GmbH, Potsdam, Germany; Rottal-Inn Kliniken KU Eggenfelden, Eggenfelden, Germany; Universitätklinikum Brandenburg an der Havel, Brandenburg an der Havel, Germany; Klinikum Fürth, Fürth, Germany; Universitätsklinikum Bonn, Bonn, Germany; St.Johannes-Hospital Dortmund, Dortmund, Germany; Krankenhaus St. Elisabeth und St. Barbara Halle (Saale) GmbH, Halle (Saale), Germany; Park-Klinik Weißensee, Berlin,