Experimental hemorrhage; prediction of mortality following acute measured hemorrhage in the dog.

H. Swan, J. Blavier, T. Marchioro, D. Jenkins, V. Montgomery
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引用次数: 8

Abstract

Introduction Heretofore, studies of the effects of hemorrhage on animals have been inextricably associated with studies of shock. A few workers have reported experiments in which the independent variable was the loss of varying volumes of blood, 1,2 but their goal was either to produce or to elucidate some mechanism of shock. Walcott 1 determined the blood volume of dogs by means of Evans blue (T-1824) and the centrifuged hematocrit. These dogs were bled from their femoral artery 41% to 58% of their measured blood volume. He found that all animals died when bled 53% or more of their blood volume. Roughly 50% of the animals bled a smaller per cent of blood volume survived. In a later paper, however, Walcott 3 states that bleeding an animal according to a fixed percentage of blood volume is an unreliable means of producing shock. Thereafter, Walcott used a modification of Mann's 4
实验性出血;预测狗急性出血后的死亡率。
迄今为止,对动物出血影响的研究一直与休克研究密不可分。一些工作人员报告了一些实验,其中的自变量是不同体积的血液损失,但他们的目标是产生或阐明休克的某些机制。Walcott 1用埃文斯蓝(T-1824)和离心红细胞压积法测定狗的血容量。这些狗的股动脉出血占其测量血容量的41%至58%。他发现,所有动物在失血超过其血容量的53%时都会死亡。大约有50%的动物流血,只有不到1%的血容量存活了下来。然而,在后来的一篇论文中,Walcott 3指出,根据固定的血容量百分比给动物放血是一种不可靠的产生休克的方法。此后,沃尔科特使用了曼恩4的修改版
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