A Charge Transfer Determination of Paracetamol with Picric Acid

Abstract

A cost effective and sensitive spectrophotometric method has been developed for the assay of paracetamol in pure and commercial forms. The method employed was charge transfer complexation. Paracetamol formed a 1:2 stoichiometric ratio with picric acid. The complex was quantified at 500nm. Beer –Lambert’s law was obeyed within a concentration range of 5-10μg/ml with molar absorptivity of 2.6 x104Lmol-1cm-1. The method was used for the determination paracetamol in pure and commercial forms with percentage mean recovery of 95%.