Clinical and Epidemiological Features of Pediatric Patients with COVID-19 in a Tertiary Pediatric Hospital

M. De Filippo, P. Magri, G. Bossi, I. Brambilla, R. Castagnoli, A. Mascolo, M. Votto, A. Licari, G. Marseglia
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引用次数: 3

Abstract

Background: Coronavirus disease 2019 (COVID-19) affects people of any age with high mortality and morbidity in adults older than 65 years. Reports on pediatric cases highlighted those children generally develop milder symptoms than adults or are asymptomatic. We aimed to assess the epidemiological and clinical data of children and adolescents with SARS-CoV-2 infection to improve pediatric COVID-19. Methods: We retrospectively analyzed clinical and epidemiological features of patients with SARS-CoV-2 infection hospitalized at the Pediatric Hospital of Pavia, Italy, between February 1, 2020, to April 30, 2021. Results: 71 patients aged 0-16 years were included; 33 (46%) females and 38 (54 %) males. Thirty-three (46%) patients had comorbidities, such as obesity and hematological diseases. Thirty-one children (44%) were exposed to COVID-19-positive household members. Nine (12.7 %) patients were asymptomatic, whereas 57 (80.3%) had a mild-moderate disease. Only five (7%) showed a severe or critical disease, and two patients required ICU admission. The most frequent symptoms were fever (76%), loss of appetite (26%), gastrointestinal symptoms (19%), and cough (19%). Chest X-ray was performed in 42 patients showing lung abnormalities in more than half of symptomatic patients. The most common laboratory features were lymphopenia and eosinopenia associated with high levels of inflammation markers. Conclusions: This study confirmed that COVID-19 has a mild course in children compared to adults. Most of the enrolled children were asymptomatic or had a mild-moderate disease. Patients with comorbidities were more prone to develop clinical complications. (www.actabiomedica.it)
某三级儿科医院新冠肺炎患儿临床及流行病学特征分析
背景:2019冠状病毒病(COVID-19)可影响任何年龄段的人,在65岁以上的成年人中死亡率和发病率都很高。关于儿科病例的报告强调,这些儿童的症状通常比成人轻微或无症状。我们旨在评估儿童和青少年SARS-CoV-2感染的流行病学和临床资料,以改善儿童COVID-19。方法:回顾性分析2020年2月1日至2021年4月30日在意大利帕维亚儿科医院住院的SARS-CoV-2感染患者的临床和流行病学特征。结果:纳入患者71例,年龄0 ~ 16岁;女性33人(46%),男性38人(54%)。33例(46%)患者有合并症,如肥胖和血液病。31名儿童(44%)与covid -19阳性家庭成员接触。9例(12.7%)患者无症状,57例(80.3%)患者有轻中度疾病。只有5例(7%)表现为严重或危重性疾病,2例需要ICU住院。最常见的症状是发热(76%)、食欲不振(26%)、胃肠道症状(19%)和咳嗽(19%)。42例患者行胸片检查,半数以上有症状的患者肺部异常。最常见的实验室特征是与高水平炎症标志物相关的淋巴细胞减少和红细胞减少。结论:本研究证实,与成人相比,儿童的COVID-19病程较轻。大多数入组儿童无症状或患有轻中度疾病。有合并症的患者更容易出现临床并发症。(www.actabiomedica.it)
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