Length of Hospitalization: A Protective Factor in a Prospective Observational Cohort Study in Brazilian ASA III and IV Hip Fracture Elderly Patients

T. Ribeiro, Ricardo Issler Unfried, Luiz Giulian Brito, K. Stein, João Alberto Larangeira, O. Monticielo
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Abstract

Background: Hip fracture is a devastating injury in elderly and the vast majorities are usually treated surgically. However, this treatment can also be non-operative, principally for patients classified at ASA III-IV. Several risk factors are associated with 1-year mortality for operated patients but a small number of studies provide the risk factors for non-operated patients. The aim of this study was to investigate the influence of hospitalization time and other risk factors on non-operated patients. Methods: A prospective observational cohort study from April 2005 to April 2012 was conducted on 286 patients aged 65 years or more with hip fracture classified at ASA III-IV for 1 year to investigate the influence of hospitalization time and the 1-year mortality risk factors. Survival time was analyzed by Kaplan-Meier curves and Cox’s regression models were used to evaluate risk factors to all subjects, operated and non-operated subjects. Results: The mortality was 73.5% for non-operated subjects. Final Cox’s regression for all subjects demonstrated that for patients that do not undergo surgery, mortality increased by six times. To operated patients, for each day of hospitalization, 1-year survival decreased 12.6 days, and ASA IV increased the mortality rate three times. To non-operated subjects, hospitalization time was a protective factor; for each day of hospitalization, 1-year survival increased 10.44 days. Conclusion: When conservative treatment is chosen for a complicated elderly, extended hospitalization should be considered. Hospitalization time has proved to be a protective factor in these cases and discharge with improved survival rates with good clinical status should be advocated. However, surgery should always be employed even for patients with poor clinical conditions. J Curr Surg. 2016;6(1):21-29 doi: http://dx.doi.org/10.14740/jcs296e
住院时间:巴西ASA III和IV期老年髋部骨折患者前瞻性观察队列研究中的保护因素
背景:髋部骨折是老年人的一种破坏性损伤,绝大多数通常采用手术治疗。然而,这种治疗也可以是非手术治疗,主要针对ASA III-IV级的患者。一些危险因素与手术患者的1年死亡率有关,但少数研究提供了未手术患者的危险因素。本研究旨在探讨住院时间及其他危险因素对非手术患者的影响。方法:于2005年4月至2012年4月对286例65岁及以上ASA III-IV级髋部骨折患者进行为期1年的前瞻性观察队列研究,探讨住院时间及1年死亡危险因素的影响。采用Kaplan-Meier曲线分析生存时间,采用Cox回归模型评价所有受试者、手术组和未手术组的危险因素。结果:非手术组死亡率为73.5%。所有受试者的最终Cox回归表明,不接受手术的患者死亡率增加了6倍。手术患者每住院1天,1年生存期减少12.6天,ASA IV使死亡率增加3倍。对于未手术的患者,住院时间是保护因素;每住院1天,1年生存期增加10.44天。结论:老年复杂患者在选择保守治疗时,应考虑延长住院时间。在这些病例中,住院时间已被证明是一个保护因素,应提倡在临床状况良好的情况下提高生存率出院。然而,即使对临床条件较差的患者,也应始终采用手术治疗。contemporary surgery . 2016;6(1):21-29 doi: http://dx.doi.org/10.14740/jcs296e
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