Hydrogen cyanamide poisoning; rare but serious, case report

Reham Radwan, N. Ramadan
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Abstract

Abstract: Background: Pesticides are used widely and are one of the major causes of intentional poisoning. Hydrogen cyanamide is highly toxic; causing massive vomiting, hypotension, shock and drowsiness. Case report: Adult male patient in the third decade was admitted to Cairo university toxicology center in January 2015 with suicidal ingestion of unknown amount of known hormonal plant regulator called DORMEX (active ingredient is hydrogen cyanamide). The patient experienced sever vomiting and diarrhea. He was tachypnic, with low blood pressure and his pupils were bilaterally constricted. ABG shows metabolic acidosis with normal other routine labs. Sodium bicarbonate was given till ABG improved. Later, the patient was shocked, Dopamine and noradrenaline were started, and then he was stabilized. Then after 5 hours patient was arrested, CPR was started, but, the patient died. Conclusion: This case may be, in our national toxicology center, the first reporting poisoning case with ingestion of hydrogen cyanamide with a suicidal intent. The case was rapidly deteriorated in spite of good supportive treatment, ended by death due to shock and refractory metabolic acidosis.
氰化氢中毒;罕见但严重,病例报告
摘要:背景:农药被广泛使用,是故意中毒的主要原因之一。氰化氢是剧毒的;导致大量呕吐,低血压,休克和嗜睡。病例报告:2015年1月,开罗大学毒理学中心收治一名30岁成年男性患者,自杀性摄入未知数量的已知激素植物调节剂DORMEX(有效成分为氰胺氢)。病人有严重的呕吐和腹泻。他呼吸急促,血压低,瞳孔双侧收缩。ABG显示代谢性酸中毒,其他常规检查正常。给予碳酸氢钠直至血球改善。随后,患者休克,开始使用多巴胺和去甲肾上腺素,病情稳定。5小时后,病人被逮捕,开始心肺复苏术,但是,病人死亡。结论:本病例可能是我国毒理学中心报告的首例有自杀意图的误食氰化氢中毒病例。尽管得到了良好的支持治疗,但病情迅速恶化,最终因休克和难治性代谢性酸中毒而死亡。
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