NMDA receptor antagonists as potential therapy in cerebellar degenerative disorders

Q3 Multidisciplinary
O. Belozor, A. Shuvaev, Y. Fritsler, A. Shuvaev
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引用次数: 0

Abstract

Cerebellar degeneration remains a poorly studied topic. Excitotoxicity, i.e. neuronal damage and death due to excess activation of postsynaptic N-methyl-D-aspartate receptors (NMDAR) by glutamate, is considered to be a universal mechanism of most neurodegenerative conditions. The use of antagonists that predominantly block NMDAR in cases of excitotoxicity is a very promising treatment strategy for neurodegenerative disorders. This review presents the known structure and function of NMDAR. Information on studies investigating the use of NMDAR antagonists in the treatment of neurodegenerative diseases is provided. Creation of new therapies to correct excitotoxicity in various neurodegenerative disorders, for example, spinocerebellar ataxias, requires further study of the subunit composition and the role of NMDAR in the cerebellum. Treatment methods that combine the use of extrasynaptic NMDAR antagonists or synaptic NMDAR agonists with drugs that affect the total amount of glutamate in the synaptic cleft are promising.
NMDA受体拮抗剂作为小脑退行性疾病的潜在治疗方法
小脑变性仍然是一个研究较少的话题。兴奋性毒性,即由于谷氨酸过度激活突触后n -甲基- d -天冬氨酸受体(NMDAR)而导致的神经元损伤和死亡,被认为是大多数神经退行性疾病的普遍机制。在兴奋性毒性的情况下,使用主要阻断NMDAR的拮抗剂是一种非常有前途的治疗神经退行性疾病的策略。本文综述了NMDAR的结构和功能。提供了研究NMDAR拮抗剂在神经退行性疾病治疗中的应用的信息。创造新的治疗方法来纠正各种神经退行性疾病(例如脊髓小脑共济失调)的兴奋性毒性,需要进一步研究NMDAR的亚基组成和在小脑中的作用。结合使用突触外NMDAR拮抗剂或突触性NMDAR激动剂与影响突触间隙中谷氨酸总量的药物的治疗方法是有希望的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Clinical and Experimental Neurology
Annals of Clinical and Experimental Neurology Medicine-Neurology (clinical)
CiteScore
0.80
自引率
0.00%
发文量
32
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