Nano-emulsion encapsulation for the efficient delivery of bacteriophage therapeutics

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-09 DOI:10.1016/j.biologicals.2023.101725

Loushambam Samananda Singh

引用次数: 0

Abstract

Antibiotic resistance has become the major concern for global public health. Phage therapy is being considered as an alternative for antibiotics to treat the multidrug resistant bacterial infections. Bacteriophage therapeutic developments has faced many challenges, including the drug formulations for sustainable phage delivery. The nano-emulsion platform has been described as the best approach to retain phage efficacy, shelf life and stability. Encapsulated phage drugs ensure stable delivery of phages to the target site and integrate in the system. In this review, our main focus is on the nano-emulsion encapsulation of bacteriophages and its effects towards the phage therapeutic development.

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用于噬菌体治疗药物有效递送的纳米乳液封装。

抗生素耐药性已成为全球公共卫生关注的主要问题。噬菌体治疗被认为是治疗多重耐药细菌感染的替代抗生素。噬菌体治疗的发展面临着许多挑战，包括可持续噬菌体递送的药物配方。纳米乳液平台被认为是保持噬菌体功效、保质期和稳定性的最佳方法。包封噬菌体药物可确保噬菌体稳定地递送到靶点并融入系统。本文就噬菌体的纳米乳剂包封及其对噬菌体治疗的影响作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.