Epidemiology and antimicrobial resistance profile of invasive non-typhoidal Salmonella from the Philippines Antimicrobial Resistance Surveillance Program, 2014-2018.

IF 1 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Western Pacific Surveillance and Response Pub Date : 2023-09-06 eCollection Date: 2023-07-01 DOI:10.5365/wpsar.2023.14.1030

Sonia B Sia, Ferissa B Ablola, Marietta L Lagrada, Agnettah M Olorosa, June M Gayeta, Marilyn T Limas, Manuel C Jamoralin, Polle Krystle V Macaranas, Holly Grace O Espiritu, June Janice B Borlasa, Emmanuel Alfred S Villamin, Ma Cecilia G Alea, Janine Elizabeth V Guia

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Abstract

Objective: The epidemiology of invasive non-typhoidal Salmonella (iNTS) in the Philippines is not well elaborated. The present study describes the serotype distribution and antimicrobial susceptibility patterns of iNTS in the Philippines from 2014 to 2018.

Methods: Invasive NTS isolates were collected through the Department of Health's Antimicrobial Resistance Surveillance Program (ARSP). The identification of the isolates was confirmed using automated (Vitek®, bioMérieux, Marcy l'Étoile, France) and conventional methods. The isolates were serotyped using the slide agglutination method, and susceptibility testing was performed using Clinical and Laboratory Standards Institute guidelines. Demographic data were collected from the ARSP database.

Results: There were 138 isolates collected from human invasive specimens with 97.8% from blood samples. The most common serotypes were Salmonella Enteritidis (n = 84, 60.9%) and Salmonella Typhimurium (n = 18, 13.0%). Most of the isolates were from males (n = 88, 63.8%) and from the 0-5-year age group (n = 61, 44.2%). The proportions of iNTS isolates resistant to first-line antibiotics were as follows: ampicillin (23.2%), chloramphenicol (9.6%), ciprofloxacin (8.7%), ceftriaxone (2.2%) and trimethoprim-sulfamethoxazole (8.8%). The proportion of isolates with multidrug resistance was 13.0% (18/138) with the most common resistance profile being resistance to ampicillin-chloramphenicol-ciprofloxacin from Salmonella Enteritidis isolates (n = 5).

Discussion: Resistance to first-line antibiotics limits the therapeutic choices for Salmonella infection. Relevant local antimicrobial resistance data on iNTS may support appropriate empiric therapy among vulnerable populations.

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菲律宾2014-2018年侵袭性非伤寒沙门氏菌耐药性监测项目流行病学及耐药性分析

目的:菲律宾侵袭性非伤寒沙门氏菌(iNTS)流行病学研究尚不完善。本研究描述了2014 - 2018年菲律宾iNTS的血清型分布和抗菌药物敏感性模式。方法:通过卫生部抗菌素耐药性监测计划(ARSP)收集侵袭性NTS分离株。采用自动(Vitek®，biom rieux, Marcy l'Étoile，法国)和常规方法对分离物进行鉴定。采用玻片凝集法对分离株进行血清分型，并按照临床与实验室标准协会的指南进行药敏试验。人口统计数据从ARSP数据库中收集。结果:从人体侵入性标本中分离到138株，其中97.8%来自血液标本。最常见的血清型为肠炎沙门菌(84例，60.9%)和鼠伤寒沙门菌(18例，13.0%)。大多数分离株为雄性(n = 88, 63.8%)和0 ~ 5岁年龄组(n = 61, 44.2%)。iNTS分离株对一线抗生素耐药比例依次为氨苄西林(23.2%)、氯霉素(9.6%)、环丙沙星(8.7%)、头孢曲松(2.2%)和甲氧苄啶-磺胺甲恶唑(8.8%)。肠炎沙门氏菌多药耐药比例为13.0%(18/138)，最常见的耐药类型为氨苄西林-氯霉素-环丙沙星(n = 5)。讨论:对一线抗生素的耐药限制了沙门氏菌感染的治疗选择。有关iNTS的当地抗菌素耐药数据可能支持对脆弱人群进行适当的经验性治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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