Adverse effect of Canaglifloxacin on bone is reversed by Puerariae radix in rat model of diabetics

Y. Asiri, A. Alqahtani, Khalid A. Asseri, K. Venkatesan, N. Khan, V. Easwaran, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraj, K. Chidambaram, K. Venkatesan
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Abstract

The root of Pueraria labata, Puerariae radix(PR), a leguminous plant that grows wild, is one of the first and most significant basic herbs used in traditional medicine for a variety of therapeutic uses. PR is high in isoflavonoids including daidzein and genistein, which have been shown to protect against bone loss caused by oestrogen insufficiency. In an osteoporotic animal model, soybean isoflavones have been shown to reduce bone loss. CGF (canagliflozin) appears to raise the risk of fractur. In diabetic rats, the potential function of PR in reversing CGFinduced bone loss was investigated. A rat model was used to investigate the effects of Puerariae radix extract (PRE) on blood glucose, HBA1C levels, and bone mineral density. Control group (vehicle therapy), Diabetic group, `PRE group, Canagliflozin (CGF), and CGF +PRE group were all made up of six Wistar albino rats. Each medication was given by gastric gavage once a day for 35 days. PRE treatment increased bone mass substantially when compared to normal controls. This suggests that PRE might be developed as an alternative therapy for osteoporosis caused by anti-diabetic drugs. Keywords: Puerariae radix, Diabetic osteoporosis, streptozotocin, Canagliflozin.
葛根可逆转加格列沙星对糖尿病大鼠骨骼的不良影响
葛根(Pueraria labata, PR)是一种野生豆科植物,是传统医学中用于各种治疗用途的第一个也是最重要的基本草药之一。PR中含有大量的异黄酮,包括大豆黄素和染料木素,它们被证明可以防止雌激素不足引起的骨质流失。在骨质疏松动物模型中,大豆异黄酮已被证明可以减少骨质流失。CGF (canagliflozin)似乎会增加骨折的风险。在糖尿病大鼠中,研究了PR在逆转cg诱导的骨质流失中的潜在功能。采用大鼠模型研究葛根提取物(PRE)对大鼠血糖、HBA1C水平和骨密度的影响。对照组(载药组)、糖尿病组、PRE组、加格列净(CGF)、CGF +PRE组均为6只Wistar白化大鼠。两种药物均以灌胃方式给予,每天1次,连用35 d。与正常对照组相比,预处理显著增加了骨量。提示PRE可作为抗糖尿病药物所致骨质疏松症的替代疗法。关键词:葛根,糖尿病骨质疏松症,链脲佐菌素,加格列净
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