Parasites: Disease or cure?

科技视界 Pub Date : 2022-01-25 DOI:10.33493/scivis.21.04.01

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Abstract

Endoparasitic infections are usually regarded as detrimental to the host causing various diseases in humans and animals especially in tropical and sub-tropical countries. In recent years, the incidence of autoimmune and other inflammatory diseases increase in developed and industrial regions. The entry of any infectious disease is challenged by the body immune system through various branch of immunity among which T-helper branches of immunity (Th1 and Th2) play at the fore-front. However, the uncurbed imbalance of Th immune response where a surge in Th1 (IFNγ and TNFα) over Th2 response is implicated to cause various autoimmune and inflammatory disorders. In general, parasitic helminth infection is fought by the body as up-regulation of Th2 branch of immunity by secreting inflammatory cytokines (Interleukins like: IL-4, IL-5, IL-9 & IL-13) thereby executing antibody-dependent cellular cytotoxicity (ADCC). In recent years, exciting evidences revealed that the uncurbed Th1 surge is brought to balance by administration of parasite or parasite extracts thereby alleviating the clinical manifestation of autoimmune and inflammatory disorders. This paper describes works that have been carried out to control various autoimmune and inflammatory disorders using parasite or parasite extracts.

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寄生虫:疾病还是治疗?

内寄生虫感染通常被认为对宿主有害，在人类和动物中引起各种疾病，特别是在热带和亚热带国家。近年来，自身免疫性疾病和其他炎症性疾病的发病率在发达地区和工业地区有所增加。任何传染病的进入都受到机体免疫系统通过各种免疫分支的挑战，其中t辅助免疫分支(Th1和Th2)起着最重要的作用。然而，当Th1 (IFNγ和TNFα)超过Th2反应时，不受抑制的Th免疫反应不平衡可能导致各种自身免疫性和炎症性疾病。一般来说，机体通过分泌炎性细胞因子(白细胞介素如:IL-4、IL-5、IL-9和IL-13)上调Th2免疫分支来对抗寄生虫感染，从而执行抗体依赖性细胞毒性(ADCC)。近年来，令人兴奋的证据表明，未经抑制的Th1激增通过给药寄生虫或寄生虫提取物得到平衡，从而减轻自身免疫性和炎症性疾病的临床表现。本文描述了利用寄生虫或寄生虫提取物控制各种自身免疫和炎症疾病的工作。

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来源期刊

科技视界

自引率

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发文量

59577

期刊介绍： Science & Technology Vision is a science and technology journal supervised by the Shanghai Association for Science and Technology and sponsored by the Shanghai Science Writers Association. It takes grassroots science and education workers as readers, popularizes scientific knowledge, tracks hot issues in science and technology at home and abroad, pays attention to new developments, new technologies, and new achievements in the forefront of the science and technology community, adheres to the combination of theory and practice, popularization and exploration, integrates scientificity, knowledge, academicity, and foresight, and builds a platform and theoretical position for academic debate for the majority of science and technology workers. Science & Technology Vision has been fully included in "China National Knowledge Infrastructure", "Chinese Science and Technology Journal (VIP) Database", "Longyuan Journal Network", "Education Reading Network", and "Wanfang Database".