Reducing the effects of paracetamol-induced hepatic damage in rat With fluvastatin drug

M. Thuwaini, Hanaa S. Kadhem, H. Hatem
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Abstract

The goal of current study was to actualization the protective effect of the probability of Fluvastatin hepatoprotection. Paracetamol (PCM) overdose can cause hepatotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In present study, the effects of Fluvastatin(10mg/kg) and (20mg/kg) on PCM-induced hepatotoxicity were examined. Rats were divided randomly into five groups containing 9 rats each.  The control group received normal saline (the vehicle). Other groups were treated with Fluvastain alone (20mg/kg), PCM alone (600mg/kg), (600mg/kg PCM + 10mg/kg Fluvastatin), and (20mg/kg PCM + 20mg/kg Fluvastatin) respectively, for 4 weeks. Paracetamol induced male rat hepatotoxicity represented by significant decline in the serum total albumin (P< 0.05). However, the study appeared significantly increment (P< 0.0001), bilirubin, ALT, AST and ALP as shown in group2 (induction group) in comparison with group1 (control group).  However, simultaneous administration of fluvastatin (10mg/kg and 20mg/kg) with paracetamol, significantely was attenuated the adverse changes in the serum total albumin, bilirubin, ALT IU/L, AST, and ALP. On the other hand, the biochemical observations were supported by histopathological examination of liver sections. Where,  showed marked attenuated the severity of paracetamol –induced hepatotoxicity, However, all these toxic effects were improved by administration of fluvastatin, but didn’t bring them to the control limits.
氟伐他汀降低扑热息痛对大鼠肝损伤的影响
本研究的目的是实现氟伐他汀肝保护概率的保护作用。对乙酰氨基酚(Paracetamol, PCM)过量可引起肝毒性,氧化应激可能是其介导机制之一。本研究观察氟伐他汀(10mg/kg)和氟伐他汀(20mg/kg)对pcm肝毒性的影响。将大鼠随机分为5组,每组9只。对照组给予生理盐水(载药)。其余组分别给予氟伐他汀单用(20mg/kg)、PCM单用(600mg/kg)、(600mg/kg PCM + 10mg/kg氟伐他汀)、(20mg/kg PCM + 20mg/kg氟伐他汀)治疗,疗程4周。对乙酰氨基酚引起雄性大鼠肝毒性,表现为血清总白蛋白显著下降(P< 0.05)。组2(诱导组)与组1(对照组)相比,胆红素、ALT、AST、ALP均显著升高(P< 0.0001)。然而,氟伐他汀(10mg/kg和20mg/kg)与扑热息痛同时施用可显著减弱血清总白蛋白、胆红素、ALT IU/L、AST和ALP的不良变化。另一方面,肝脏切片的组织病理学检查支持生化观察。其中,对乙酰氨基酚引起的肝毒性明显减轻,氟伐他汀可改善这些毒性作用,但未达到对照限度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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