evaluation of arrival metaphylaxis with enrofloxacin compared to tulathromycin in feedlot cattle at high risk of developing bovine respiratory disease in Mexico

L. Burciaga-Robles, C. McMullen, A. Bras, Mariana Guerra-Maupome, Rodolfo A. Nava-Gaspar, R. Rademacher, S. Hannon, Victor E. Mercado-Talamantes, C. Booker
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Abstract

  In this large-pen commercial field trial, mixed beef-breed bulls and heifers were randomly allocated at feedlot arrival to 1 of 2 experimental groups: ENRO or TULA. Animals in the ENRO group (10 multi-pen lots; 2037 animals) received a subcutaneous injection of enrofloxacin at a dosage of 3.4 mg/lb (7.5 mg/kg) body weight once at allocation. Animals in the TULA group (10 multi-pen lots; 2036 animals) received a subcutaneous in­jection of tulathromycin at a dosage of 1.1 mg/lb (2.5 mg/kg) body weight once at allocation. Study animals were housed by experimental group in commercial feedlot pens and fol­lowed from allocation until slaughter. There were no statisti­cal differences detected in any of the animal health or feedlot performance outcome variables between the experimental groups at the P < 0.050 level. Given the lack of detectable sta­tistical differences in animal health and feedlot performance outcome variables in the current study, the relative cost effec­tiveness of metaphylaxis programs utilizing enrofloxacin or tulathromycin in mixed beef-breed bulls and heifers at high risk of developing bovine respiratory disease should be depen­dent on the relative cost of each program, as well as any intan­gible attributes such as syringability, storage requirements, potential for antimicrobial resistance, etc.
评价恩诺沙星与图拉霉素在墨西哥发生牛呼吸道疾病高风险的饲养场牛中的到达性过敏反应
在本大型猪圈商业大田试验中,在到达饲养场时,将混合牛种公牛和小母牛随机分为2个实验组:ENRO组或TULA组。ENRO组动物(10个多栏;2037只动物在分配时皮下注射恩诺沙星,剂量为3.4 mg/lb (7.5 mg/kg)体重。TULA组动物(10个多栏;2036只动物)在分配时皮下注射图拉霉素,剂量为1.1 mg/lb (2.5 mg/kg)体重。实验动物由试验组饲养在商业饲养场围栏内,从分配到屠宰。各组动物健康和饲养场生产性能指标均无统计学差异(P < 0.050)。鉴于在目前的研究中缺乏可检测到的动物健康和饲养场性能结果变量的统计差异,使用恩诺沙星或图拉霉素对发生牛呼吸道疾病高风险的混合牛种公牛和小母牛进行过敏反应计划的相对成本效益应取决于每个计划的相对成本,以及任何无形属性,如注射性、储存要求、潜在的抗菌素耐药性等。
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