Rein et médicaments

Abstract

The interaction between drugs and the kidney can be considered at different levels: normal drug clearance, influence of the renal function on their elimination, expression of the drug nephrotoxicity, and their elimination in case of overdosing. In the child, available information often consists in extrapolated observations from adult subjects, and sometimes from animal experiments. It is therefore important to clearly identify the paediatric features of the drugs-kidney relationship, insofar as they considerably vary from the foetal period towards adolescence.