Risk Estimation of Aortic Stiffness in Patients with End Stage Renal Disease under Maintenance Haemodialysis

University Heart Journal Pub Date : 2019-02-17 DOI:10.3329/UHJ.V14I2.40285

Rasul Amin, A. Razzak, G. Hasan, A. A. Hai, Chayan Kumar Singho, S. E. Mahbub, F. Kabir, Haque Ma, Elora Sharmin

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Abstract

Background: The stiffness of the large elastic arteries increase the morbidity and mortality. Objective: The purpose of the present study was to estimate the risk of aortic stiffness among end stage renal disease patients under maintenance haemodialysis. Methodology: This case-control study was carried out in the Department of Nephrology at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka and National Institute of Cardiovascular Disease and Hospital (NICVD), Dhaka, Bangladesh from January 2013 to December 2014 for a period of two (02) years. Chronic kidney disease in stage 5 [CKD-5(D)] patients older than 18 years on maintenance haemodialysis (MHD) for more than 3 months were designated as case group and age and sex matched non CKD patients were considered as control group. Serum calcium, serum albumin, serum phosphate and iPTH were estimated by semi-automated biochemistry analyzer from the Department of Biochemistry of NIKDU, Dhaka and NICVD, Dhaka. Plain X-ray abdomen in lateral view was performed for all patients. Result: A total number of 100 patients were enrolled for this study of which 50 patients were in end stage renal disease (ESRD) group and the rest 50 patients were in non-CKD group. Mean (±SD) aortic stiffness index was significantly higher (P<0.001) among ESRD population (3.27±1.70) compared to non CKD group of population (2.00±0.73). Mean (±SD) serum calcium (corrected) level was significantly high (P<0.001) in ESRD patients (9.79±0.87) compared to non CKD group of population (9.13±0.70). Mean (±SD) serum phosphate level was significantly higher (P<0.001) in ESRD patients (5.71±0.96) compared to non CKD group of population (4.20±0.59). However, mean (±SD) iPTH level showed no significant difference between ESRD (25.33±51.98) and non CKD group of population (38.53±19.52). Conclusion: In conclusionaortic stiffness is significantly higher among ESRD subjects. University Heart Journal Vol. 14, No. 2, Jul 2018; 67-70

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终末期肾病患者维持血液透析时主动脉僵硬的风险评估

背景:大弹性动脉的僵硬增加了发病率和死亡率。目的:本研究的目的是评估维持血液透析的终末期肾病患者主动脉僵硬的风险。方法:本病例对照研究于2013年1月至2014年12月在孟加拉国达卡国立肾脏疾病和泌尿外科研究所(NIKDU)肾病科和孟加拉国达卡国立心血管疾病和医院研究所(NICVD)进行，为期两年(02)。慢性肾脏疾病5期[CKD-5(D)]患者年龄大于18岁，维持血液透析(MHD)超过3个月为病例组，年龄和性别匹配的非CKD患者为对照组。血清钙、血清白蛋白、血清磷酸盐和iPTH由达卡NIKDU生物化学系和达卡NICVD的半自动生化分析仪测定。所有患者均行腹部侧位平片。结果:共纳入100例患者，其中终末期肾病(ESRD)组50例，非ckd组50例。ESRD组平均(±SD)主动脉硬度指数(3.27±1.70)明显高于非CKD组(2.00±0.73)(P<0.001)。ESRD患者平均(±SD)血钙(校正)水平(9.79±0.87)明显高于非CKD组(9.13±0.70)(P<0.001)。ESRD患者的平均(±SD)血清磷酸盐水平(5.71±0.96)明显高于非CKD组(4.20±0.59)(P<0.001)。ESRD组iPTH水平(25.33±51.98)与非CKD组iPTH水平(38.53±19.52)差异无统计学意义。结论:ESRD患者主动脉僵硬度明显增高。《大学心脏杂志》2018年7月第14卷第2期;67 - 70

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University Heart Journal

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