IMMUNIZATION OF MICE WITH KILLED E. coli K99 VACCINE FOR PROTECTION AGAINST COLIBACCILLOSIS

Abstract

Enterotoxigenic E. coli is the most common enteropathogen that causes diarrhea in newborn farm animals. The bacteria cause diarrhea by adhering to colonizing and producing enterotoxins in the small intestine they are not invasive [2]. Enterotoxigenic E. coli (ETEC) strains as the important cause of sever diarrhea in newborn calves carry fimbriae (such as F5 (K99) and F41) mediating binding of the bacteria to microvilli of enterocytes of the small intestine [3,4]. Osman, et al [5] report that the large and small ruminants could be a potential source of infection with enterovirulent Escherichia coli pathotypes in humans in Egypt.