Evaluation of antianxiety and antidepressant activity of aqueous extract of Cynodon dactylon (Doob grass) in Swiss albino mice

Saroj Kothari
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引用次数: 1

Abstract

Objective: Anxiety and depression are common psychiatric conditions that cause changes in the lifestyle of humans and impose huge costs for the treatment to the patients. The present study was carried out to find antianxiety and antidepressant activity of aqueous extract of Cynodon dactylon (AECD) in mice. Methods: AECD was prepared by maceration method. The yield was 5% w/w. The AECD was screened for antianxiety activity by elevated plus maze (EPM) and light and dark box and for antidepressant activity by forced swim test (FST) and tail suspension test (TST) in mice. For each model, animals were divided in four groups of six animals. Group I served as control and received gum acacia aqueous suspension 10 ml/kg. Groups II and III served as test group and received AECD 200 and 400 mg/kg, respectively. Group IV served as standard group and received diazepam 1 mg/kg for antianxiety activity and fluoxetine (20 mg/kg) for antidepressant activity. All drugs were administered by gavage. Results: AECD 200 and 400 mg/kg showed significant (P 0.05) with that of fluoxetine in both the models. Conclusion: Results of our study su
犬牙草水提物对瑞士白化小鼠的抗焦虑和抗抑郁活性评价
目的:焦虑和抑郁是引起人类生活方式改变的常见精神疾病,给患者带来巨大的治疗费用。本研究旨在研究短爪蟹水提物(AECD)对小鼠的抗焦虑和抗抑郁作用。方法:采用浸渍法制备AECD。产量为5% w/w。采用升高+迷宫法(EPM)和明暗箱法(light and dark box)筛选AECD抗焦虑活性,采用小鼠强迫游泳试验(FST)和悬尾试验(TST)筛选AECD抗抑郁活性。对于每个模型,动物被分成四组,每组6只。ⅰ组为对照组,给予金合欢胶水混悬液10 ml/kg。II组、III组为试验组,分别给予AECD 200、400 mg/kg。IV组为标准组,给予安定1 mg/kg抗焦虑作用和氟西汀20 mg/kg抗抑郁作用。所有药物均采用灌胃给药。结果:AECD 200、400 mg/kg与氟西汀在两种模型中的差异均有统计学意义(P < 0.05)。结论:我们的研究结果是可靠的
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