Calcium, Phosphorus and PTH in Patients with End Stage of Chronic Kidney Disease, Undergoing Hemodialysis

S. Faja, A. Shoshi
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Abstract

Renal hyperparathyroidism (rHPT) is a common complication of chronic kidney disease characterized by elevated parathyroid hormone levels secondary to derangements in the homeostasis of calcium, phosphate, and vitamin D. Patients with rHPT experience increased rates of cardiovascular problems and bone disease. The Kidney Disease: Improving Global Outcomes guidelines recommend that screening and management of rHPT be initiated for all patients with chronic kidney disease stage 3 (estimated glomerular filtration rate, - 60 mL/min/1.73 m2). Since the 1990s, improving medical management with vitamin D analogs, phosphate binders, and calcimimetic drugs has expanded the treatment options for patients with rHPT, but some patients still require a parathyroidectomy to mitigate the sequelae of this challenging disease.
终末期慢性肾病血液透析患者钙、磷和甲状旁腺激素的变化
肾性甲状旁腺功能亢进(rHPT)是一种常见的慢性肾脏疾病并发症,其特征是继发于钙、磷酸盐和维生素d体内平衡紊乱的甲状旁腺激素水平升高。肾脏疾病:改善全球结局指南建议对所有慢性肾脏疾病3期(估计肾小球滤过率- 60 mL/min/1.73 m2)患者进行rHPT筛查和管理。自20世纪90年代以来,使用维生素D类似物、磷酸盐结合剂和拟钙化药物改善医疗管理,扩大了rHPT患者的治疗选择,但一些患者仍然需要甲状旁腺切除术来减轻这种具有挑战性的疾病的后遗症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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