Investigation of Age-Related Alterations in Brain and Serum Samples in a Healthy Aging Rat Model

Q3 Pharmacology, Toxicology and Pharmaceutics

Fabad Journal of Pharmaceutical Sciences Pub Date : 2023-01-31 DOI:10.55262/fabadeczacilik.1228030

E. Özer

引用次数: 0

Abstract

Male albino rats of Wistar strain (n=24) were assigned to three groups 2-month old (GRP I), 9-month old (GRP II) and 15-month old (GRP III) ,(n=8 in each ) in order to investigate age related changes in serum and brain samples. Malondialdehyde (MDA), reduced glutathione (GSH), acetylcholinesterase (AChE) and paraoxanase (PON) enzyme activites , soluble and aggregated amyloid β1-42 (Aβ1-42) levels were analyzed in brain tissues. Tissues were also stained with Congo-red dye in order to observe fibrillation. Serum total cholesterol, uric acid and triglyceride levels and PON activites were investigated. Serum uric acid levels were significantly decreased (p

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健康衰老大鼠模型中脑和血清样本年龄相关改变的研究

选取Wistar株雄性白化大鼠24只，分为2月龄(GRP I)、9月龄(GRP II)和15月龄(GRP III) 3组，每组8只，观察血清和脑组织的年龄相关性变化。测定脑组织丙二醛(MDA)、还原性谷胱甘肽(GSH)、乙酰胆碱酯酶(AChE)和对氧氧化酶(PON)活性、可溶性和聚集性淀粉样蛋白β1-42 (Aβ1-42)水平。同时用刚果红染色观察纤维性颤动。测定血清总胆固醇、尿酸、甘油三酯水平及PON活性。血清尿酸水平显著降低(p

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来源期刊

Fabad Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.80

自引率

0.00%

发文量

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