Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy

Abstract

In this study, the relationship between MSI (microsatellite instability) and the parameters such as age, stage, histologic grade, recurrence, overall survival (OS), disease free survival (DFS) were investigated in 99 endometrioid adenocancer patients. Our aim is to find out the whether there is a prognostic value of MSI in endometrium adenocarcinoma. In MSI analysis, by employing the Promega MSI Analysis System. ‘IBM SPSS v.20’ was used for statistical analysis. MSI was identified in 19.1% of patients. There was no statistically significant effect of MSI on OS (p = 0.404) or on DFS (p = 0.407). MSI was found associated with younger age (p = 0.032), lymph node involvement (p = 0.012) and advanced stage (p = 0.014).