Characterization of polymeric films for transdermal drug delivery

Abstract

Drug-free films of different polymers were prepared by casting solvent technique employing mercury as a substrate. The physical and chemical properties of the films were evaluated for their potential transdermal use. The films were found to be stable and intact at ambient temperature and humidity conditions. The results indicate that the polymeric films of hydroxypropyl methyl cellulose (HPMC), polyvinyl acetate (PVA), carboxymethyl cellulose (CMC), cellulose acetate (CA), ethyl acetate (EC) and Eudragit RL100 & S100 along with those of polyvinyl pyrrolidone (PVP), and propylene glycol (PPG) as plasticizer appear promising for the development of suitable transdermal drug delivery systems (TDDS).