Modification of bone repair hydroxyapatite scaffold by hydrothermal method with assistance of copperions: Testing the angiogenesis using Chick Chorioallantoic Membrane as ex vivo model

2018 International Conference on Computer, Control, Electrical, and Electronics Engineering (ICCCEEE) Pub Date : 2018-08-01 DOI:10.1109/ICCCEEE.2018.8515824

Adil Elrayah, Shi Feng, J. Weng, Abdullah Aldhafeeri

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Abstract

The angiogenesis in the surface of hydroxyapatite scaffolds materials for bone repair was studied by establishing Chick Chorioallantoic Membrane model. Chick Chorioallantoic Membrane model with heavy vascularization was prepared to explore the angiogenesis formations. Hydroxyapatite scaffold has been coated hydrothermally with assistance of copper ions to improve its properties. The morphology of the new product was changed to the flower-like shape (micro/nano-structure) compared with uncoated scaffold. The optical camera, optical microscopic and scanning electron microscope were used to charcterized the investigated results. The investigated results implied that the modified (coated) scaffold can promoted angiogenesis formations compared with the uncoated scaffold. Furthermore, the present tests with chicken chorioallantoic membrane model allow a convenient, efficient, and low-cost method of exploring the angiogenesis on scaffolds surfaces.

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铜离子辅助羟基磷灰石骨修复支架的水热法修饰:以鸡绒毛膜尿囊膜为离体模型进行血管生成试验

通过建立鸡毛囊尿囊膜模型，研究羟基磷灰石骨修复支架材料表面血管生成情况。制备了重血管化鸡绒毛膜尿囊膜模型，探讨其血管生成机制。利用铜离子对羟基磷灰石支架进行水热包覆以改善其性能。与未涂覆支架相比，新产品的形态改变为花状(微/纳米结构)。利用光学相机、光学显微镜和扫描电镜对研究结果进行了表征。研究结果表明，与未包被支架相比，修饰后的支架可以促进血管生成。此外，本实验采用鸡绒毛膜尿囊膜模型，为探索支架表面血管生成提供了一种方便、高效、低成本的方法。

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2018 International Conference on Computer, Control, Electrical, and Electronics Engineering (ICCCEEE)

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