Simple and rapid dipstick test for detection of dexamethasone adulteration in traditional herbal medicines

Q4 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical Sciences Asia Pub Date : 2021-01-01 DOI:10.29090/PSA.2021.02.19.148

B. Kuswandi, Arimbi S Kartika, Nia Kristiningrum, D. K. Pratoko, Indah Purnama Sary

引用次数: 2

Abstract

Simple, rapid, and low-cost dipstick test has been fabricated for the detection of dexamethasone adulteration in traditional herbal medicine (Jamu) for the joint-pain killer. The dipstick test has been constructed by immobilization of FeCl3 and K3[Fe(CN)6] in cellulose acetate film as a sensing film toward dexamethasone. The sensing film changes its color from green to blue in the presence of dexamethasone. It has response time at 10 mins and good linearity in the range 0.5-75 μg/ml of dexamethasone with correlation coefficient (r) of 0.9997, with the detection limit, was 0.422 μg/ml. The dipstick tests have been successfully used for the detection of dexamethasone adulteration in jamu for the joint-pain killer, and the result demonstrated in good correlation with the UV spectrophotometry method. Thus, the dipstick test is simple, rapid, and low-cost; it can be used as an alternative method for the detection of dexamethasone adulteration in traditional herbal medicine.

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简易快速试纸法检测中草药中地塞米松掺假

建立了一种简便、快速、低成本的关节止痛中药(Jamu)中掺假地塞米松的检测方法。将FeCl3和K3[Fe(CN)6]固定在醋酸纤维素薄膜中作为地塞米松的传感膜，构建了试纸试验。在地塞米松的作用下，传感膜的颜色由绿色变为蓝色。在0.5 ~ 75 μg/ml范围内线性良好，相关系数(r)为0.9997，检出限为0.422 μg/ml。应用量尺法对关节止痛药加木中地塞米松的掺假进行了检测，结果与紫外分光光度法具有良好的相关性。因此，试纸测试简单、快速、低成本;该方法可作为传统中草药中地塞米松掺假检测的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.