기능성차 개발을 위한 아위느타리 버섯 발효액 추출물의 아세틸콜린에스테라제 저해활성에 관한 연구

Association for International Tea Culture Pub Date : 2022-12-31 DOI:10.21483/qwoaud.58..202212.135

Hee-Kyung Lee, On-you Choi, Hyun-suk Choi, Myung-ja Lee, Kwanghyun Yu

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Abstract

This study was to investigate the inhibitory activity of oxidation and acetylcholinesterase using acetone, hexane, ethyl acetate, hot water and ethanol extracts of mycelia obtained from submerged culture from Pleurotus eryngii (DC. ex Fr.) Quel. var. ferulae Lanzi for function tea development. Among various solvent extracts on the oxidation inhibitory activity, the ethanol extract obtained 66.18% of the maximum inhibitory activity. In the case of acetylcholinesterase inhibitory activity, the hot water extract obtained 13.24% of the maximum inhibitory activity. The maximum inhibitory activity of acetylcholinesterase was obtained 17.36% at 40℃ of extract temperature. The maximum inhibitory activity of oxidation was obtained 63.28% at 60℃. The oxidation inhibitory activity was increased from 50.63 to 60.17% when extract time was increased from 2hr to 4hr at 60℃. On the other hand, in the case of over 6hr of extract time, it was decreased to 55.43% at 12hr of extract time. Thermal and pH of acetylcholinesterase inhibitor were stable at 10-30℃ and pH 5.0 to 9.0. As a result, it is considered that this pretreatment effect is effective in promoting inhibitory activity of acetylcholinesterase and oxidation using P. eryngii (DC. ex Fr.) Quel. var. ferulae Lanzi mycelia.

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旨在开发功能性性别差异的紫丁香菇发酵液提取物乙酰胆碱酯阻抗活性研究

采用丙酮、己烷、乙酸乙酯、热水和乙醇等提取液对杏鲍菇(Pleurotus eryngii, DC)菌丝体的氧化和乙酰胆碱酯酶的抑制活性进行了研究。(原译)奎尔兰子阿魏用于功能茶的开发。在各种溶剂提取物的氧化抑制活性中，乙醇提取物获得了66.18%的最大抑制活性。在抑制乙酰胆碱酯酶活性的情况下，热水提取物的抑制活性最高为13.24%。在提取温度为40℃时，乙酰胆碱酯酶的抑制活性最高，为17.36%。在60℃时，其氧化抑制活性最高达63.28%。60℃提取时间由2小时延长至4小时，抗氧化活性由50.63%提高到60.17%。另一方面，在提取时间超过6hr的情况下，在提取时间为12hr时，这一比例下降到55.43%。乙酰胆碱酯酶抑制剂在10 ~ 30℃、pH 5.0 ~ 9.0时热稳定，pH稳定。综上所述，该预处理效果可有效促进青霉对乙酰胆碱酯酶和氧化的抑制活性。(原译)奎尔阿魏变种兰氏菌丝。

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Association for International Tea Culture

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