Holmium for Use in Cancer Therapy

IF 3.8 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Comments on Inorganic Chemistry Pub Date : 2017-06-12 DOI:10.1080/02603594.2017.1333498

Yi Shi, A. Johnsen, A. D. Di Pasqua

引用次数: 7

Abstract

Over the last few decades, holmium (Ho) has been investigated for its application in laser surgery, magnetic resonance imaging, and internal and topical radionuclide therapy. Ho has a 100% natural abundance of holmium-165, which is a stable nuclide that can undergo a process called neutron-activation to generate radioactive holmium-166 (166Ho). 166Ho emits β–particles and γ photons, with a half-life of 26.8 h; β–particles can damage a cancer cell’s DNA, while γ photons allow for 166Ho to be imaged in vivo and easily quantitated prior to, or during, dosing. This article gives a thorough account of the work being done around the world on 166Ho for use as an internal or topical radionuclide therapy against cancer. Our research group and others have generated compelling data that support the use of 166Ho as a radiotherapeutic in the clinic, especially since pharmaceutical formulations can be made while non-radioactive (Ho) and then made radioactive (166Ho) just prior to use. Graphical Abstract

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钬用于癌症治疗

在过去的几十年里，人们对钬(Ho)在激光手术、磁共振成像以及内部和局部放射性核素治疗中的应用进行了研究。Ho的天然丰度为100%，这是一种稳定的核素，可以经历一个称为中子活化的过程，产生放射性的钬-166 (166Ho)。166Ho发射β粒子和γ光子，半衰期为26.8 h;β -粒子可以破坏癌细胞的DNA，而γ光子允许166Ho在体内成像，并且在给药前或给药期间容易定量。本文全面介绍了世界各地关于166Ho作为抗癌内用或外用放射性核素治疗的工作。我们的研究小组和其他人已经产生了令人信服的数据，支持在临床中使用166Ho作为放射治疗药物，特别是因为药物配方可以在非放射性(Ho)的情况下制成，然后在使用之前制成放射性(166Ho)。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comments on Inorganic Chemistry 化学-无机化学与核化学

CiteScore

9.00

自引率

1.90%

发文量

审稿时长

>12 weeks

期刊介绍： Comments on Inorganic Chemistry is intended as a vehicle for authoritatively written critical discussions of inorganic chemistry research. We publish focused articles of any length that critique or comment upon new concepts, or which introduce new interpretations or developments of long-standing concepts. “Comments” may contain critical discussions of previously published work, or original research that critiques existing concepts or introduces novel concepts. Through the medium of “comments,” the Editors encourage authors in any area of inorganic chemistry - synthesis, structure, spectroscopy, kinetics and mechanisms, theory - to write about their interests in a manner that is both personal and pedagogical. Comments is an excellent platform for younger inorganic chemists whose research is not yet widely known to describe their work, and add to the spectrum of Comments’ author profiles, which includes many well-established inorganic chemists.