The Protective Effect of Moringa Oleifera Seeds Extract on Liver Damage in Mice

Abstract

The current study to assess the antioxidant and hepatoprotective properties of Moringa oleifera seed extract versus carbon tetrachloride (CCl4)-stimulated liver damage. Materials &Methods: Male albino mice were separated into four groups for the investigation The control group (A) was given distilled water (DW), whereas the other three groups (B, C, and D) were administered CCl4 intraperitoneally (IP) (0.5 ml/kg) mixed with corn oil (vol/vol), for 8 weeks, twice a week. Group (C) was given Moringa seed extract (1g/kg) orally every day for 8 weeks, while group (D) was given corn oil orally, and the groups (C) and (D) were compared to group (B) which was given CCl4 IP. The researchers measured liver functions, blood-reduced glutathione (GSH), total antioxidant capacity (TAC), and malondialdehyde (MDA) in erythrocytes. Moreover, catalase enzymes in liver tissue homogenate were also assayed and superoxide dismutase (SOD), in addition to liver histopathology. Results : Following a CCl4 injection, liver enzymes and MDA levels were elevated. Conversely, TAC, serum albumin, total protein, catalase, tissue SOD, and blood glutathione levels were all decreased. Administration to Moringa oleifera seeds extract reduces MDA levels and enzyme activity in the liver while increasing antioxidant activity. Simultaneously, after treatments with this extract, the histological damage effects of CCl4 intoxication were also improved. Conclusion: Finally, Moringa oleifera seeds extract increased innate antioxidant activity and reduced CCl4-induced liver damage, suggesting that it might be employed as a hepatoprotective medication in the future.