The Effect of an Aqueous Extract of Illicium verum on Serum Levels of Thyroid Hormones and Depression, Anxiety, and Stress in Patients With Hypothyroidism

Y. Koushan, Ahmad Yari Khosroushahi, M. H. Geranmayeh, S. Hashemipour, Mahnaz Ghadimi Yari, H. K. Haghighian
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Abstract

Background: Hypothyroidism has been associated with complications such as increased inflammation, and oxidative stress. Objective: This pilot study was created to assess the impact of Illicium verum (I. verum) on serum levels of thyroid hormones as well as depression, anxiety, and stress in hypothyroidism patients given the detrimental effects of oxidative stress on thyroid function and considering the antioxidant properties of I. verum. Methods: In this double-blind clinical research with a placebo group, which was performed as a pilot, 20 hypothyroid individuals were recruited. Participants were randomly allocated to a capsule containing 1.5 g of I. verum (per day) (n=10) or a placebo (n=10) for 8 weeks. Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured at the beginning and end of the study. Furthermore, depression and stress were assessed using the Depression Anxiety Stress Scales-21 (DASS-21) survey. Quantitative analysis was performed using SPSS software, version 20. Findings: No discernible difference was observed between the blood thyroid hormone levels at the baseline. TSH levels in the intervention group decreased significantly at the end of the study, while FT3, FT4, T3, and T4 levels increased significantly (P<0.05). Compared to the study’s initial findings, the intervention group experienced considerably lower mean changes in terms of depression, anxiety, and stress scores. (P<0.05). Conclusion: The I. verum supplement can be helpful as a dietary supplement with antioxidant properties in patients with hypothyroidism. This herbal supplement can increase the effectiveness of medication in patients with hypothyroidism.
八角水提物对甲状腺功能减退患者血清甲状腺激素水平及抑郁、焦虑和应激的影响
背景:甲状腺功能减退与炎症增加和氧化应激等并发症有关。目的:考虑到氧化应激对甲状腺功能的不利影响,并考虑到八头草的抗氧化特性,本初步研究旨在评估八头草(I. verum)对甲状腺功能低下患者血清甲状腺激素水平以及抑郁、焦虑和应激的影响。方法:本双盲临床研究以安慰剂组为先导,招募20例甲状腺功能低下患者。参与者被随机分配到含有1.5 g verum(每天)的胶囊(n=10)或安慰剂(n=10),持续8周。在研究开始和结束时测量甲状腺激素,包括游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)和促甲状腺激素(TSH)。此外,使用抑郁焦虑压力量表-21 (DASS-21)调查评估抑郁和压力。采用SPSS软件20进行定量分析。结果:基线时血液甲状腺激素水平无明显差异。干预组在研究结束时TSH水平显著降低,FT3、FT4、T3、T4水平显著升高(P<0.05)。与研究的初始结果相比,干预组在抑郁、焦虑和压力得分方面的平均变化要低得多。(P < 0.05)。结论:枳实可作为抗氧化性膳食补充剂用于甲状腺功能减退患者。这种草药补充剂可以增加甲状腺功能减退患者的药物治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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