Improved Knoevenagel Condensation Protocol for the Synthesis of Cyanoacrylates and their Anticancer Activity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-09 DOI:10.29356/jmcs.v67i1.1835

Hari Babu Bolikolla, Santha Kumari Merugu

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Abstract

DIPEAc (diisopropylethylammonium acetate) has been used as a catalyst in the Knoevenagel condensation of aldehydes and ethyl cyanoacetate to produce cyanoacrylate with high yields. The reaction's key characteristics are a shorter reaction time, a large substrate scope, the viability of different functional groups, ease of work-up, and high yields, which provide environmental benefits. Furthermore, the anticancer activity of the synthesized series of cyanoacrylate derivatives was tested against A549, HT-29, and HepG2 cell lines. Resumen. El aetato de diisopropiletilamonio (DIPEAc) se empleó como catalizador en la reacción de condensación de Knoevenagel emplenado aldehídos y cianoacetato de etilo para producir cianoacrilatos en reindimientos elevados. Algunas características de esta aplicación es el que requiere tiempos cortos de reacción, se puede practicar en una amplia gama de sustratos, tolera varios grupos funcionales, el trabajo de la reacción es sencillo y tiene elvados rendimientos, lo que es compatible con el medio ambiente. Los productos obtenidos fueron probados con las líneas celulares A549, HT-29 y HepG2.

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改进Knoevenagel缩合法合成氰基丙烯酸酯及其抗癌活性

DIPEAc (diisopropylethylammonium acetate)你也被用来作为催化剂的in the Knoevenagel condensation of aldehydes and ethyl cyanoacetate to produce cyanoacrylate with high yields。该反应的主要特点是反应时间短、底物范围广、不同功能组的可行性、易于操作和产量高，提供环境效益。此外，还对合成的氰基丙烯酸酯衍生物系列对A549、HT-29和HepG2细胞系的抗癌活性进行了测试。摘要。以二异丙基乙酸乙酯铵(DIPEAc)为催化剂，将醛与氰酸乙酸乙酯进行Knoevenagel缩合反应，高产产氰酸丙烯酸酯。该应用的一些特点是反应时间短，可以在广泛的基材上进行，耐多个官能团，反应工作简单，产量高，与环境兼容。在本研究中，我们评估了两种不同的方法，一种是在实验室中进行的，另一种是在实验室中进行的。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.