A Functional Assessment Tool to Distinguish Controls From Alzheimer's Disease in Lima, Peru.

American Journal of Alzheimer's Disease & Other Dementias® Pub Date : 2022-01-01 DOI:10.1177/15333175221104354

Nilton Custodio, Rosa Montesinos, Diego Chambergo-Michilot, Eder Herrera-Perez, Maritza Pintado-Caipa, Wendy Seminario G, José Cuenca, Laura Mesía, Virgilio E Failoc-Rojas, Monica M Diaz

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Abstract

Background: The Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer's disease (ad). We evaluated its performance in controls, Peruvians with MCI or AD.

Methods: A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach's alpha) and validity were assessed.

Results: We enrolled 276 individuals (ad: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC: .996), and Cronbach's alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate ad severity. The ADCS-ADL correlated highly with nearly all tools.

Conclusions: The ADCS-ADL scale is reliable in a population with ad in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.

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秘鲁利马用于区分对照组和阿尔茨海默病的功能评估工具。

背景：阿尔茨海默病合作研究-日常生活活动（ADCS-ADL）量表是一种针对阿尔茨海默病患者的多功能功能评估工具。我们评估了它在对照组、患有 MCI 或 AD 的秘鲁人中的表现：方法：对在利马（秘鲁）神经病学研究所就诊的患有轻度认知障碍（MCI）、老年痴呆症或认知健康的老年人进行横断面研究。评估了重测可靠性（类内相关系数，ICC；内部一致性，Cronbach's alpha）和有效性：我们共招募了 276 人（广告：113 人，MCI：68 人，对照组：95 人），他们在年龄、性别、教育程度和抑郁症状方面均无差异。信度理想（ICC：.996），Cronbach's alpha 适当（.937）。ADCS-ADL 无法区分 MCI 和对照组，但可以区分广告的严重程度。ADCS-ADL与几乎所有工具都高度相关：ADCS-ADL量表在秘鲁利马的广告患者中是可靠的。结论：ADCS-ADL量表在秘鲁利马的广告患者中是可靠的，未来的工作可能会验证一种适用于教育水平较低的秘鲁人的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American Journal of Alzheimer's Disease & Other Dementias®

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