A New Predictor for Insulin Resistance in Polycystic Ovary Syndrome: InsuTAG

IF 0.3 Q4 OBSTETRICS & GYNECOLOGY

Current Women s Health Reviews Pub Date : 2023-03-01 DOI:10.2174/1573404820666230301115706

T. Omma, Aksanur Gokce, M. Celik, I. Karahan, C. Culha, N. Gulcelik

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引用次数: 0

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women of reproductive age. PCOS leads to metabolic dysfunction such as dyslipidemia, obesity, and glucose intolerance based on hyperandrogenemia, hyperinsulinemia, and dysregulated adipokine secretion. The aim of this study was to investigate whether a new marker, InsuTAG (fasting insulin×fasting triglycerides) could predict insulin resistance (IR) in patients of PCOS. In this study, retrospective data of 300 female patients diagnosed with PCOS were analyzed. The relationship between InsuTAG and HOMA-IR, TyG, and TG/HDL-C scores related to insulin resistance was evaluated. In addition, the distribution of the cases according to the cut-off values was determined. Log-transformed forms of InsuTAG and HOMA-IR, TyG and TG/HDL-C results were positively correlated, respectively. (r=0.85, p<0.001; r₌0.78,p<0.001; r₌0.72, p<0.001). Sensitivity, specificity, positive predictive value and negative predictive values for InsuTAG were calculated as 85%, 85%, 82% and 88%, respectively. This study is the first to compare the InsuTAG, another predictor of insulin resistance, with other IR markers in women with PCOS. InsuTAG is a novel biomarker based on plasma sampling of insulin and triglyceride, with minimally invasive, inexpensive and orientally accessible features.

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多囊卵巢综合征胰岛素抵抗的新预测指标:InsuTAG

多囊卵巢综合征(PCOS)是育龄妇女最常见的内分泌疾病。多囊卵巢综合征导致代谢功能障碍，如血脂异常、肥胖和基于高雄激素血症、高胰岛素血症和脂肪因子分泌失调的葡萄糖耐受不良。本研究的目的是探讨一种新的标记物InsuTAG(空腹insulin×fasting甘油三酯)是否可以预测PCOS患者的胰岛素抵抗(IR)。本研究回顾性分析了300例女性多囊卵巢综合征患者的资料。评估InsuTAG与胰岛素抵抗相关的HOMA-IR、TyG和TG/HDL-C评分之间的关系。根据截断值确定病例的分布，InsuTAG的对数变换形式与HOMA-IR、TyG和TG/HDL-C结果分别呈正相关。(r = 0.85, p < 0.001;r₌0.78,p < 0.001;r₌0.72,p < 0.001)。InsuTAG的敏感性、特异性、阳性预测值和阴性预测值分别为85%、85%、82%和88%。这项研究首次比较了胰岛素抵抗的另一个预测指标InsuTAG与多囊卵巢综合征女性的其他IR标志物。InsuTAG是一种基于血浆胰岛素和甘油三酯采样的新型生物标志物，具有微创、廉价和易于获取的特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Women s Health Reviews OBSTETRICS & GYNECOLOGY-

CiteScore

0.70

自引率

25.00%

发文量

期刊介绍： Current Women"s Health Reviews publishes frontier reviews on all the latest advances on obstetrics and gynecology. The journal"s aim is to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all clinicians and researchers in the fields of obstetrics and gynecology.