Pharmacotechnical development and evaluation of the physicochemical stability of a cosmetic gel from Aloe vera mucilage

Abstract

Background: Aloe vera is a medicinal plant of the family Xanthorrhoeaceae found in tropical regions, better known as slug. It has medicinal and cosmetic properties. The present work aimed to develop a gel based on Aloe vera with cosmetic action in capillary application. Materials and Methods: A qualitative and quantitative analysis of the following components was used for the development: Carbomer, propylene glycol and methylparaben in order to identify the best formulation. The samples were made in triplicate and stored in three different conditions: hothouse, refrigerator and room temperature, where they were submitted to tests. The data obtained were used to evaluate the organoleptic and physicochemical characteristics. Results: The results obtained from the organoleptic characteristics presented variations and instability in their color, odor and appearance. The formulations presented different results even the samples being exposed to the same conditions. Only one formulation underwent changes considered significant having the need for stabilization of its physicochemical constituents. And the others presented satisfactory results to our research. Conclusions: When evaluating the physico-chemical characteristics, we analyzed the pH, density and spreadability of each sample and no formulation presented significant changes where they remained within the range of values established by the quality control guide for cosmetic products of the Agencia Nacional de Vigilância Sanitaria (ANVISA).