Cryptococcus neoformans Meningoencephalitis with Multiple Cerebral Infarctions in a non-HIV Patient

Abstract

new infarction in the pons. The patient eventually died of aspiration pneumonia. Autopsy revealed C. neoformans infiltrating the perivascular spaces of the perforating branches of the middle cerebral and basilar artery regions, with inflammation and thrombotic occlusions of these vessels. This case serves to highlight the fact that it is the thrombosis caused by the significant perivascular inflammation, and not infiltration of the vessels by C. neoformans itself, that plays the major role in the pathogenesis of cerebral infarction in non-HIV patients with C. neoformans meningoencephalitis.