Effects of Exercise Training Intensity on Plasma Levels of Creatinine Kinas After a Myocardial Infarction in Male Wistar Rats

A. Zokaei, M. Ghahramani
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Abstract

Background: The creatine phosphokinase-MB (CPK-MB) isoenzyme level is useful in determining the myocardial infarction (MI) extent and time. Evidence indicates the possible effect of exercise training on reducing the amount of CPK-MB, but the proper intensity of exercise is still unclear. Objectives: In this study the effect of intensity of exercise training on creatinine kinas after a myocardial infarction in plasma levels of male Wistar rats was comparing. Methods: Thirty two male Wistar rats at 10 weeks of age were divided in to four groups [low (N = 8), moderate (N = 8), and high (N = 8) intensity interval training and a control (N = 8) group (no exercise)]. Six weeks later, rats became MI patients through surgery. CPK-MB plasma levels were investigated before training, immediately after training for six weeks as well as 12 hours after MI. The data were analyzed by ANOVA with repeated measure and Tukey (α ≥ 0.05). Results: The results showed that changes in CK enzyme at 12 hours after MI in LIIT (113.88 ± 19.25), MIIT (135.88 ± 35.58) and HIIT (105.75 ± 19.05) were statistically significant compared to the control group (124.62 ± 23.41) only in 12 hours after MI and this reduction in the low-intensity interval training group was significant than the other two groups (P = 0.0001). Conclusions: In this study, six weeks of interval training with each intensity was likely to make cardiac cells resistant to necrosis resulting in low levels of the CPK-MB enzyme compared to the control group after the myocardial infarction event.
运动训练强度对雄性Wistar大鼠心肌梗死后血浆肌酐激酶水平的影响
背景:肌酸磷酸激酶- mb (CPK-MB)同工酶水平可用于判断心肌梗死(MI)的程度和时间。有证据表明运动训练可能对降低CPK-MB的量有影响,但适当的运动强度尚不清楚。目的:比较运动训练强度对雄性Wistar大鼠心肌梗死后血浆肌酐激酶水平的影响。方法:将32只10周龄雄性Wistar大鼠分为4组[低(N = 8)、中(N = 8)、高(N = 8)强度间歇训练组和对照组(N = 8)(不运动)]。6周后,大鼠通过手术成为心肌梗死患者。分别于训练前、训练后6周及心肌梗死后12小时测定血浆CPK-MB水平。数据采用重复测量的方差分析(ANOVA)和Tukey分析(α≥0.05)。结果:心肌梗死后12 h, LIIT组CK酶(113.88±19.25)、MIIT组(135.88±35.58)、HIIT组(105.75±19.05)仅在心肌梗死后12 h与对照组(124.62±23.41)比较,CK酶的变化有统计学意义,低强度间歇训练组CK酶的变化显著高于其他两组(P = 0.0001)。结论:在这项研究中,与对照组相比,在心肌梗死事件后,每种强度的6周间歇训练可能使心肌细胞抵抗坏死,导致CPK-MB酶水平较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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